Epidemiology, clinical presentations and burden of rotavirus diarrhea in children under five seen at Ramathibodi Hospital, Thailand.
Epidemiology, clinical presentations and burden of rotavirus diarrhea in children under five seen at Ramathibodi Hospital, Thailand.
复制标题
泰国 Ramathibodi 医院五岁以下儿童轮状病毒腹泻的流行病学、临床表现和负担。
DOI：
--
复制
发表时间：
2008
影响因子：
--
通讯作者：
W. Varavithaya
中科院分区：
文献类型：
--
作者：
U. Intusoma;Vorasith Sornsrivichai;C. Jiraphongsa;W. Varavithaya
背景
为了能够在将来监测轮状病毒疫苗的影响，作者沿着泰国轮状病毒监测项目设计了本研究。
目的
调查泰国轮状病毒引起腹泻的流行病学、临床表现和直接医疗费用
材料和方法
对研究期间所有腹泻病例的临床表现进行分析，用聚丙烯酰胺凝胶电泳证实轮状病毒腹泻。血清学分型采用逆转录-聚合酶链反应。
结果
2001年4月至2002年3月，239 5岁以下的腹泻病例在Ramathibodi医院，泰国被确定，临床表现和实验室结果进行了分析，从85例。轮状病毒检出率为48.2%。最常见的血清型分别为G9（67%）、G4（23%）和GI（2%）。轮状病毒腹泻的最常见年龄为12-17个月。季节高峰期是2001年11月至2002年1月（泰国的凉爽和干燥季节）。主要症状为水样腹泻、发热和呕吐。轮状病毒性腹泻比其他原因更容易引起脱水和代谢性酸中毒。G4血清型与最严重的介绍。
结论
本研究中轮状病毒腹泻的比例为48%。每个儿童每次轮状病毒腹泻的平均直接医疗费用为2，101泰铢（约52美元）。
BACKGROUND
To be able to monitor the impact of rotavirus vaccines in the future, the authors designed the present study along with the Rotavirus Surveillance Project-Thailand.
OBJECTIVE
To examine the epidemiology, clinical presentation, and direct medical cost of rotavirus-caused diarrhea in Thailand
MATERIAL AND METHOD
Clinical presentations of all diarrhea cases during the study period were analyzed Rotavirus diarrhea was confirmed with polyacrylamide gel electrophoresis. Serological typing was characterized by reverse transcription-polymerase chain reaction.
RESULTS
Between April 2001 and March 2002, 239 under 5-year-old diarrhea cases admitted in Ramathibodi Hospital, Thailand were identified Clinical presentations and laboratory results were analyzed from 85 cases. Rotavirus was identified in 48.2% of the specimens. The most common serotypes were G9 (67%), G4 (23%), and GI (2%) respectively. The most common age of rotavirus diarrhea was 12-17 months. The seasonal peak was during November 2001 to January 2002 (the cool and dry season in Thailand). The predominant symptoms were watery diarrhea, fever, and vomiting. Rotavirus diarrhea tended to have more dehydration and metabolic acidosis than other causes. The G4 serotype was associated with the most severe presentations.
CONCLUSION
The proportion of rotavirus diarrhea in the present study was 48%. The mean direct medical cost per episode of rotavirus diarrhea per child was 2,101 baht (approximately 52 US $).
周Y：“1995年至1997年在日本和泰国分离的人轮状病毒血清型G9的特征。”J Med Virol。
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--