AUDITORY-THRESHOLDS IN RATS OF DIFFERENT AGE AND STRAIN - A BEHAVIORAL AND ELECTRO-PHYSIOLOGICAL STUDY
AUDITORY-THRESHOLDS IN RATS OF DIFFERENT AGE AND STRAIN - A BEHAVIORAL AND ELECTRO-PHYSIOLOGICAL STUDY
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DOI：
10.1016/0378-5955(82)90069-7
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发表时间：
1982-01-01
期刊：
影响因子：
2.8
通讯作者：
BORG, E
中科院分区：
文献类型：
--
作者：
BORG, E
本研究采用条件性舔抑制法和听性脑干反应（ABR）法，对白化病大鼠的听觉敏感性进行了行为学和电生理学研究。行为阈值用10 Hz FM声测得，ABR用1/1或1/3倍频程滤波正弦波测得。研究了个体变异性、反应的重复性以及性别、年龄和品系的影响。对噪声性高频听力损失动物的行为学和电生理学技术进行了比较。正常听觉灵敏度的最高程度为. apprx。12-24 kHz。20只大鼠的变异性为0.000000。15分贝。在幼龄动物中，品系和性别没有影响。在老年高血压大鼠中观察到高频听力灵敏度的恶化;血压正常的大鼠仅显示出最小的变化。用电生理学（ABR）技术获得的阈值比行为学获得的阈值高10-20 dB。这两种技术（行为和1/3倍频程ABR）评估高频听力损失同样好。显然，ABR（1/3倍频程滤波正弦波）适用于听力阈值的测定和听力损失的评估，至少在高频范围内。ABR技术在长期实验中特别有用，在此期间，阈值被反复确定。
The auditory sensitivity of albino rats was determined behaviorally by conditioned suppression of licking and electrophysiologically by the auditory brain stem response (ABR). The behavioral thresholds were obtained with 10-Hz FM tones, and the ABR with 1/1- or 1/3-octave filtered sine waves. Individual variability, reproducibility of responses and the influence of sex, age and strain were investigated. The behavioral and electrophysiological techniques were compared in animals with noise induced high-frequency hearing losses. The highest degree of normal auditory sensitivity was .apprx. 12-24 kHz. The variability in 20 rats was .apprx. 15 dB. In young animals, strain and sex had no influence. A deterioration in high-frequency hearing sensitivity was observed in aged hypertensive rats; normotensive rats showed only minimal changes. The thresholds obtained with the electrophysiological (ABR) technique were 10-20 dB higher than those obtained behaviorally. Both techniques (behavioral and 1/3-octave ABR) assess high-frequency hearing loss equally well. Apparently, the ABR (1/3-octave filtered sine waves) is suitable for the determination of hearing thresholds and the assessment of hearing loss, at least in the high-frequency range. The ABR technique is especially useful in long-term experiments during which thresholds are determined repeatedly.