Alcohol consumption significantly influences the MR signal of frontal choline-containing compounds
Alcohol consumption significantly influences the MR signal of frontal choline-containing compounds
复制标题
DOI：
10.1016/j.neuroimage.2006.03.049
复制
发表时间：
2006-08-15
期刊：
影响因子：
5.7
通讯作者：
Mann, Karl
中科院分区：
文献类型：
--
作者：
Ende, Gabriele;Walter, Sigi;Mann, Karl
这项工作的目的是评估一组社会饮酒者的酒精消费量和额叶中含胆碱化合物（Cho）的磁共振波谱信号之间的关系。进行了两项独立的长回波（TE = 135 ms）H-1 MRSI研究，第一项研究包括24名饮酒量非常低的受试者，第二项研究包括18名饮酒量更广泛的受试者。在MR检查前的最后90天内，额叶白色物质和前扣带回陀螺的Cho测量值与饮酒量之间存在显著相关性，年龄、性别和吸烟对代谢物测量值没有显著影响。排除体素白色物质含量的影响并没有改变胆碱测量与饮酒量的相关性。从酒精消费和额叶Cho信号的正相关性的反复发现的主要结论是，监测酒精消费是强制性的MRS研究中，病理依赖Cho的变化是假设。(c)2006年爱思唯尔公司All rights reserved.
The aim of this work was to evaluate the relationship between the amount of alcohol consumption of a group of social drinkers and the magnetic resonance spectroscopy signal of choline-containing compounds (Cho) in the frontal lobe. Two independent long echo (TE = 135 ms) H-1 MRSI studies, the first comprising 24 subjects with very low alcohol consumption, the second 18 subjects with a more widespread alcohol consumption were conducted. Significant correlations of Cho measures from frontal white matter and from the anterior cingulate gyros with alcohol consumption in the last 90 days prior to the MR examination were found. Age, gender, and smoking did not show significant effects on the metabolite measures. Partialling out the effect of the voxel white matter content did not change the correlation of choline measures with alcohol consumption. The main conclusion from the repeated finding of a positive correlation of alcohol consumption and frontal Cho signals is that monitoring for alcohol consumption is mandatory in MRS studies where pathology depended Cho changes are hypothesized. (c) 2006 Elsevier Inc. All rights reserved.