Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential.
Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential.
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DOI：
10.3389/fimmu.2017.00570
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发表时间：
2017
影响因子：
7.3
通讯作者：
Lünemann JD
中科院分区：
文献类型：
--
作者：
Keller CW;Freigang S;Lünemann JD
携带高度保守的半恒定T细胞受体（TCR）的自然杀伤T细胞[恒定自然杀伤T（iNKT）细胞]是识别由CD1d分子呈递的糖脂的非常规T淋巴细胞的子集。尽管CD1d在多种造血和非造血细胞上表达，但树突状细胞（DCs）是体内糖脂抗原的关键提呈者。当通过其TCR刺激时，iNKT细胞迅速分泌大量细胞因子并诱导DC成熟，从而促进先天性和适应性免疫应答的协调刺激。DC和iNKT细胞之间的双向串扰决定了iNKT细胞靶向应答的功能结果，并且iNKT细胞激动剂被用作佐剂以增强抗肿瘤免疫疗法的功效，并且目前正在对其进行评估。这篇综述阐明了DC和iNKT细胞相互作用的机制基础，并讨论了如何利用这些机制进行癌症治疗。
Natural killer T cells carrying a highly conserved, semi-invariant T cell receptor (TCR) [invariant natural killer T (iNKT) cells] are a subset of unconventional T lymphocytes that recognize glycolipids presented by CD1d molecules. Although CD1d is expressed on a variety of hematopoietic and non-hematopoietic cells, dendritic cells (DCs) are key presenters of glycolipid antigen in vivo. When stimulated through their TCR, iNKT cells rapidly secrete copious amounts of cytokines and induce maturation of DCs, thereby facilitating coordinated stimulation of innate and adaptive immune responses. The bidirectional crosstalk between DCs and iNKT cells determines the functional outcome of iNKT cell-targeted responses and iNKT cell agonists are used and currently being evaluated as adjuvants to enhance the efficacy of antitumor immunotherapy. This review illustrates mechanistic underpinnings of reciprocal DCs and iNKT cell interactions and discusses how those can be harnessed for cancer therapy.