TMS and TMS-EEG techniques in the study of the excitability, connectivity, and plasticity of the human motor cortex
TMS and TMS-EEG techniques in the study of the excitability, connectivity, and plasticity of the human motor cortex
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DOI：
10.1515/revneuro-2013-0019
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发表时间：
2013-08-01
影响因子：
4.1
通讯作者：
Rossini, Paolo Maria
中科院分区：
文献类型：
--
作者：
Ferreri, Florinda;Rossini, Paolo Maria
越来越多的证据支持这样一种观点，即大脑可塑性涉及不同的功能和结构成分，每个成分都涉及在一个极其复杂的框架内不同时间尺度、突触位点和发育阶段运行的许多细胞机制。然而，大脑可塑性/连通性现象的功能和结构成分之间的确切关系仍不清楚，其解释是现代神经科学的主要挑战。经颅磁刺激（TMS），有或没有脑电图（EEG），是一种敏感和客观的测量不同类型的非侵入性操作的大脑活动，特别是运动皮层的影响。此外，TMS和TMS- eeg共配准的关键特征是它们在追踪大脑功能和有效连接的时间动态和内部层次方面的关键作用，可能阐明大脑可塑性的一些基本问题。综上所述，本文的研究结果对于采用经颅磁刺激和经颅磁-脑电图共配准技术作为基础神经生理学研究的工具，甚至在未来用于临床诊断具有重要意义。
Increasing evidence supports the notion that brain plasticity involves distinct functional and structural components, each entailing a number of cellular mechanisms operating at different time scales, synaptic loci, and developmental phases within an extremely complex framework. However, the exact relationship between functional and structural components of brain plasticity/connectivity phenomena is still unclear and its explanation is a major challenge within modern neuroscience. Transcranial magnetic stimulation (TMS), with or without electroencephalography (EEG), is a sensitive and objective measure of the effect of different kinds of noninvasive manipulation of the brain's activity, particularly of the motor cortex. Moreover, the key feature of TMS and TMS-EEG coregistration is their crucial role in tracking temporal dynamics and inner hierarchies of brain functional and effective connectivities, possibly clarifying some essential issues underlying brain plasticity. All together, the findings presented here are significant for the adoption of the TMS and TMS-EEG coregistration techniques as a tool for basic neurophysiologic research and, in the future, even for clinical diagnostics purposes.