Patterns of relationships between cardiovascular disease risk factors and neurocognitive function in African Americans.
Patterns of relationships between cardiovascular disease risk factors and neurocognitive function in African Americans.
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DOI：
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发表时间：
2008
影响因子：
3.2
通讯作者：
R. Sims;S. Madhere;C. Callender;A. Campbell
中科院分区：
文献类型：
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作者：
R. Sims;S. Madhere;C. Callender;A. Campbell
目的：心血管疾病（CVD）风险与神经认知功能之间的关系在健康和社会科学文献中引起了广泛的关注；然而，在非裔美国人样本中，几种心血管疾病危险因素与神经认知功能之间的关系尚未得到充分探讨。本研究的目的是检查四种心血管疾病危险因素和五种高级皮质功能之间的关系模式。方法从华盛顿特区市区106名居住在社区的非裔美国成年人中收集数据。一名护士收集了研究参与者的血压、腰围和血液样本（用于评估甘油三酯和高密度脂蛋白（HDL）胆固醇）。参与者完成了符号数字模态测试、Trailmaking B、Stroop Color-word Task、California Verbal Learning Test- ii和Wisconsin Card Sorting Test作为神经认知功能的评估。典型分析和多元回归分析是评价心血管疾病危险因素与神经认知功能关系的主要统计方法。结果：1)注意过程与舒张压水平相关，2)语言学习过程与舒张压和甘油三酯水平相关，3)认知集转换能力与高密度脂蛋白胆固醇水平相关。结论随着我国社会，特别是少数民族心血管健康状况的恶化，必须清楚地了解其神经认知后果。未来的研究应侧重于通过纵向研究设计和脑成像技术来识别和建立心血管和神经认知联系的意识。
OBJECTIVE The association between cardiovascular disease (CVD) risk and neurocognitive function has gathered a good deal of attention in the health and social science literature; however, the relationship among several CVD risk factors and neurocognitive function has not been fully explored in an African American sample. The purpose of this study was to examine the pattern of relationships among four CVD risk factors and five measures of higher cortical functions. METHODS Data were collected from a sample of 106 African American community-dwelling adults in the metropolitan Washington, DC, area. A nurse collected blood pressure, waist circumference, and a blood sample (to assess triglycerides and high-density lipoprotein (HDL) cholesterol) from study participants. Participants completed the Symbol Digit Modalities Test, Trailmaking B, Stroop Color-word Task, California Verbal Learning Test-II, and Wisconsin Card Sorting Test as assessments of neurocognitive function. Canonical analysis and multiple regression analysis were the major statistical methods utilized to assess relationships between CVD risk factors and neurocognitive function. RESULTS The results suggest that 1) attentional processes are associated with diastolic blood pressure levels, 2) verbal learning processes are associated with diastolic blood pressure and triglyceride levels, and 3) the ability to shift cognitive set is associated with HDL cholesterol levels. CONCLUSION As cardiovascular health worsens in our society, particularly among ethnic minorities, the neurocognitive consequences must be clearly understood. Future studies should focus on identifying and building awareness of cardiovascular and neurocognitive links through longitudinal research designs and brain imaging technology.