Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
Autoimmune thrombocytopenia related to chronic hepatitis C virus infection
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DOI：
10.1179/102453309x385106
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发表时间：
2009-02-01
期刊：
影响因子：
1.9
通讯作者：
Lampe, E.
中科院分区：
文献类型：
--
作者：
de Almeida, A. J.;Campos-de-Magalhaes, M.;Lampe, E.
自从1989年丙型肝炎病毒（HCV）被鉴定为与HCV感染相关的许多肝外改变的病原体以来，已经假定潜在的免疫介导的发病机制。HCV相关性血小板减少症可能被认为是复杂的和多因素的起源，因为不同的机制已涉及其病理生理学。关于慢性HCV感染中的自身免疫性血小板减少症，仅在少数研究中报道了针对血小板糖蛋白的特异性抗体的检测，但尚未进行系统的研究。我们检查了10例自身免疫性血小板减少症患者的临床、实验室和病毒学特征（血小板计数，
Since the identification of hepatitis C virus (HCV) in 1989 as a causative agent for a number of the extrahepatic alterations related to HCV infection an underlying immune mediated pathogenetic mechanism has been postulated. HCV-associated thrombocytopenia may be considered complex and multifactorial in origin, since different mechanisms have been implicated in its pathophysiology. With respect to autoimmune thrombocytopenia in chronic HCV infection, the detection of specific antibodies against platelet glycoproteins have been reported only in a few studies, but no systematic study has been carried out. We examined the clinical, laboratory, and virological characteristics of a case series of 10 patients with autoimmune thrombocytopenia (platelet count,