Thyrotropin-releasing hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine-treated neonatal rats in vitro.
Thyrotropin-releasing hormone reverses the supersensitively depressed monosynaptic transmission by serotonin in 5,7-dihydroxytryptamine-treated neonatal rats in vitro.
复制标题
在体外经 5,7-二羟色胺治疗的新生大鼠中，促甲状腺素释放激素可逆转血清素超敏抑制的单突触传递。
DOI：
10.1016/0006-8993(94)91625-x
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发表时间：
1994
期刊：
影响因子：
2.9
通讯作者：
Warnick,JE
中科院分区：
文献类型：
--
作者：
Deshpande,SB;Warnick,JE
The interaction of serotonin and thyrotropin-releasing hormone (TRH) on onosynaptic reflex (MSR) in isolated neonatal spinal cords was examined. Superfusion of serotonin (1–30 μM) in untreated cords, depressed the MSR in a dose-dependent manner. The depression was about 25% at 10 μM of serotonin, in either control or vehicle-treated groups. While for the same concentratio oof serotonin, the depression was 97±2.1% of the control in cords from 5,7 dihydroxytryptamine (5,7-DHT)-treated animals. The inhibition of the reflex seen in cords obtained from 5,7 DHT-treated animals could not be reversed by washing with normal physiological solution (>60 min) or in presence of serotonin antagonists. TRH (0.03–1.0 μM) reversed the depression in a concentration-dependent manner and complete reversal could be seen with 1 μM of TRH. These observations indicate that, serotonin and TRH act dissimilarly on the spinal synaptic transmission though they are known to coexist in the descending bulbospinal tracts.
