Report on the National Eye Institute's Audacious Goals Initiative: Creating a Cellular Environment for Neuroregeneration.
Report on the National Eye Institute's Audacious Goals Initiative: Creating a Cellular Environment for Neuroregeneration.
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DOI：
10.1523/eneuro.0035-18.2018
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发表时间：
2018-03
期刊：
影响因子：
3.4
通讯作者：
Stevens B
中科院分区：
文献类型：
--
作者：
Burns ME;Stevens B
中枢神经系统的细胞环境不允许生长和再生。在视网膜中，干细胞的移植由于存活率低以及与现有回路的整合而受到限制。 2016 年 11 月，作为国家眼科研究所大胆目标计划 (AGI) 的一部分，一群不同的研究人员聚集在一起参加了一个研讨会，致力于阐明知识差距、进步障碍以及了解视网膜内细胞环境的新方法的想法以及如何操纵这些环境。在此过程中，该小组确定了（1）视网膜和视神经胶质细胞、（2）小胶质细胞和炎症以及（3）细胞外基质（ECM）和视网膜脉管系统区域作为推进我们对视网膜微环境的理解和操纵的关键。我们在这里为更广泛的科学界总结了研讨会的发现。
The cellular environment of the CNS is non-permissive for growth and regeneration. In the retina, transplantation of stem cells has been limited by inefficient survival and integration into existing circuits. In November 2016, as part of the National Eye Institute’s Audacious Goals Initiative (AGI), a diverse collection of investigators gathered for a workshop devoted to articulating the gaps in knowledge, barriers to progress, and ideas for new approaches to understanding cellular environments within the retina and how these environments may be manipulated. In doing so, the group identified the areas of (1) retinal and optic nerve glia, (2) microglia and inflammation, and the (3) extracellular matrix (ECM) and retinal vasculature as key to advancing our understanding and manipulation of the retinal microenvironments. We summarize here the findings of the workshop for the broader scientific community.