Noxious lingual stimulation influences the excitability of the face primary motor cerebral cortex (face MI) in the rat
Noxious lingual stimulation influences the excitability of the face primary motor cerebral cortex (face MI) in the rat
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DOI：
10.1152/jn.90609.2008
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发表时间：
2008-09-01
影响因子：
2.5
通讯作者：
Sessle, B. J.
中科院分区：
文献类型：
--
作者：
Adachi, K.;Murray, G. M.;Sessle, B. J.
口面疼痛影响运动功能的机制知之甚少。目的是确定1）舌痛觉化学刺激是否影响由皮质内微刺激（ICMS）定义的面部初级运动大脑皮层（面部MI）兴奋性;以及2）任何此类影响仅限于驱动伤害性刺激附近肌肉的运动传出MI区。氯胺酮麻醉的Sprague-Dawley雄性大鼠被植入肌电图（EMG）电极到前二腹肌，咬肌和颏舌肌肌肉。在38只大鼠中，将三个微电极位于ICMS定义的左侧面部MI部位，以引起二腹肌和/或颏舌肌反应。每15分钟测定一次ICMS诱发各部位EMG活动的阈值，持续1小时，然后用谷氨酸（1.0 M，n = 18）或等渗盐水（n = 7）输注（20 μ l，120 μ l/h）右前舌。随后，每15 min测定ICMS阈值，持续4 h。在完整对照大鼠（n = 13）中，记录5 h内的ICMS阈值。只有左侧和右侧颏舌肌ICMS阈值显著增加（
The mechanisms whereby orofacial pain affects motor function are poorly understood. The aims were to determine whether 1) lingual algesic chemical stimulation affected face primary motor cerebral cortex (face MI) excitability defined by intracortical microstimulation (ICMS); and 2) any such effects were limited to the motor efferent MI zones driving muscles in the vicinity of the noxious stimulus. Ketamine-anesthetized Sprague-Dawley male rats were implanted with electromyographic (EMG) electrodes into anterior digastric, masseter, and genioglossus muscles. In 38 rats, three microelectrodes were located in left face MI at ICMS-defined sites for evoking digastric and/or genioglossus responses. ICMS thresholds for evoking EMG activity from each site were determined every 15 min for 1 h, then the right anterior tongue was infused (20 mu l, 120 mu l/h) with glutamate (1.0 M, n = 18) or isotonic saline (n = 7). Subsequently, ICMS thresholds were determined every 15 min for 4 h. In intact control rats (n = 13), ICMS thresholds were recorded over 5 h. Only left and right genioglossus ICMS thresholds were significantly increased (