Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia
Transcriptome Analysis Identifies LINC00152 as a Biomarker of Early Relapse and Mortality in Acute Lymphoblastic Leukemia
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DOI：
10.3390/genes11030302
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发表时间：
2020-03-01
期刊：
影响因子：
3.5
通讯作者：
Jimenez-Morales, Silvia
中科院分区：
文献类型：
--
作者：
Alberto Barcenas-Lopez, Diego;Carlos Nunez-Enriquez, Juan;Jimenez-Morales, Silvia
在过去的十年中，有证据表明长非编码RNA(LncRNAs)在白血病发生中的作用。这些基因可作为儿童急性淋巴细胞白血病(ALL)的诊断和/或预后的生物标志物。为了了解lncRNAs是否与早期复发和早期死亡相关，基于微阵列的基因表达分析在B系ALL儿童(B-ALL)中进行。进行COX回归分析。计算危险比(HR)和95%可信区间(95%CI)。LINC00152和LINC01013是早期复发和早期死亡患者中差异表达最多的基因。LINC00152高表达的复发和死亡风险分别为HR：4.16(95%CI：1.46~11.86)和HR：1.99(95%CI：0.66~6.02)，LINC01013低表达的复发和死亡风险分别为HR：3.03(95%CI：1.14~8.05)和HR：6.87(95%CI：1.50~31.48)。这些结果根据NCI危险标准和化疗方案进行了调整。LINC00152的LINC00152共表达分析表明，LINC00152可能调控细胞底物黏附和肽基-酪氨酸自磷酸化等生物学过程中涉及的基因。本研究结果提示，LINC00152基因可能是B-ALL患儿复发的潜在生物标志物。
Evidence showing the role of long non-coding RNAs (lncRNAs) in leukemogenesis have emerged in the last decade. It has been proposed that these genes can be used as diagnosis and/or prognosis biomarkers in childhood acute lymphoblastic leukemia (ALL). To know if lncRNAs are associated with early relapse and early mortality, a microarray-based gene expression analysis in children with B-lineage ALL (B-ALL) was conducted. Cox regression analyses were performed. Hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated. LINC00152 and LINC01013 were among the most differentially expressed genes in patients with early relapse and early mortality. For LINC00152 high expression, the risks of relapse and death were HR: 4.16 (95% CI: 1.46-11.86) and HR: 1.99 (95% CI: 0.66-6.02), respectively; for LINC01013 low expression, the risks of relapse and death were HR: 3.03 (95% CI: 1.14-8.05) and HR: 6.87 (95% CI: 1.50-31.48), respectively. These results were adjusted by NCI risk criteria and chemotherapy regimen. The lncRNA-mRNA co-expression analysis showed that LINC00152 potentially regulates genes involved in cell substrate adhesion and peptidyl-tyrosine autophosphorylation biological processes. The results of the present study point out that LINC00152 could be a potential biomarker of relapse in children with B-ALL.