Induction of immunity to human immunodeficiency virus type-1 by vaccination.
Induction of immunity to human immunodeficiency virus type-1 by vaccination.
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DOI：
10.1016/j.immuni.2010.09.011
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发表时间：
2010-10-29
期刊：
影响因子：
32.4
通讯作者：
Haynes BF
中科院分区：
文献类型：
--
作者：
McElrath MJ;Haynes BF
最近的研究结果使人们乐观地认为，人类免疫缺陷病毒1型（HIV-1）疫苗的成功开发指日可久。对HIV-1感染早期事件的研究揭示了HIV-1在何时何地可能容易受到疫苗靶向免疫反应的影响。随着人类单克隆抗体生产技术的进步，关于抗体如何识别HIV-1包膜蛋白的线索揭示了免疫原设计的新抗原靶点。最近的一种疫苗方案显示出对HIV-1感染的适度疗效。然而，诱导长期T细胞和B细胞记忆和应对HIV-1多样性仍然是当务之急。先天免疫介质可能在阻断感染和塑造免疫中起关键作用；正在加紧调查捕捉这些活动的疫苗战略。主要挑战仍然是整合基础、临床前和临床研究，以改进对与疫苗效力相关的免疫类型的预测，将这些见解应用于免疫原设计，并加速评估疫苗对有感染风险的人的效力。
Recent findings have brought optimism that development of a successful human immunodeficiency virus type-1 (HIV-1) vaccine lies within reach. Studies of early events in HIV-1 infection have revealed when and where HIV-1 is potentially vulnerable to vaccine-targeted immune responses. With technical advances in human monoclonal antibody production, clues about how antibodies recognize the HIV-1 envelope proteins have uncovered new antigenic targets for immunogen design. A recent vaccine regimen has shown modest efficacy against HIV-1 acquisition. However, inducing long-term T and B cell memory and coping with HIV-1 diversity remain a high priority. Mediators of innate immunity may play pivotal roles in blocking infection and shaping immunity; vaccine strategies to capture these activities are under intense investigation. Key challenges remain in integrating basic, preclinical and clinical research to improve predictions of types of immunity associated with vaccine efficacy, to apply these insights to immunogen design, and to accelerate evaluation of vaccine efficacy in persons at-risk for acquiring infection.
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DOI：
10.1084/jem.20070784
发表时间：
2007-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Almeida JR;Price DA;Papagno L;Arkoub ZA;Sauce D;Bornstein E;Asher TE;Samri A;Schnuriger A;Theodorou I;Costagliola D;Rouzioux C;Agut H;Marcelin AG;Douek D;Autran B;Appay V
通讯作者：
Appay V
影响因子：
168.9
作者：
Buchbinder, Susan P.;Mehrotra, Devon V.;Duerr, Ann;Fitzgerald, Daniel W.;Mogg, Robin;Li, David;Gilbert, Peter B.;Lama, Javier R.;Marmor, Michael;del Rio, Carlos;McElrath, M. Juliana;Casimiro, Danilo R.;Gottesdiener, Keith M.;Chodakewitz, Jeffrey A.;Corey, Lawrence;Robertson, Michael N.
通讯作者：
Robertson, Michael N.
影响因子：
3.7
作者：
Davis, Katie L.;Gray, Elin S.;Shaw, George M.
通讯作者：
Shaw, George M.
影响因子：
5.5
作者：
Catanzaro, Andrew T.;Roederer, Mario;Graham, Barney S.
通讯作者：
Graham, Barney S.
影响因子：
4.4
作者：
Cao, JH;McNevin, J;McElrath, MJ
通讯作者：
McElrath, MJ