Preferential sites of growth of human tumors in nude mice following subcutaneous transplantation.
Preferential sites of growth of human tumors in nude mice following subcutaneous transplantation.
复制标题
皮下移植后裸鼠体内人类肿瘤的优先生长部位。
作者：
A. A. Kyriazis;A. Kyriazis
研究了人肿瘤移植到裸鼠两个不同解剖区域的生长特性和生物学行为。我们观察到，移植在胸壁前外侧的肿瘤比移植在躯干后侧的肿瘤生长得快。与后方移植的肿瘤相比，前方生长的肿瘤血管化更好，坏死较少，侵袭肿瘤床，转移到区域淋巴结。这些发现与它们的组织发生和形态特征无关。因此，局部血管供应是影响移植肿瘤生物学行为的关键因素，也可能影响肿瘤对治疗的反应。
The growth characteristics and biological behavior of human tumors transplanted s.c. into two different anatomical regions of nude mice were studied. It was observed that tumors trnasplanted in the anterior lateral thoracic wall grew faster than did tumors transplanted in the posterior aspect of the trunk. Anteriorly growing tumors, in contrast to the posteriorly transplanted ones, were better vascularized, showed less necrosis, invaded the tumor bed, and metastasized to the regional lymph nodes. These findings were independent of their histogenetic and morphological characteristics. It is concluded that regional vascular supply is a key factor influencing the biological behavior of the transplanted tumors and that it may affect tumor response to treatment as well.