Glucose-6-phosphatase activity in the hypothalamus of the ob/ob mouse.
Glucose-6-phosphatase activity in the hypothalamus of the ob/ob mouse.
复制标题
ob/ob 小鼠下丘脑中的葡萄糖-6-磷酸酶活性。
DOI：
10.1016/s0026-0495(98)90021-x
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Landau,BR
中科院分区：
文献类型：
--
作者：
Khan,A;Zong-Chao,L;Efendic,S;Landau,BR
The hypothalamus and cortex from ob ob mice and their lean littermates were sonicated and then incubated with glucose-6-phosphate (glucose-6-P) and glycerol phosphate (glycerol-P). The difference between the rates of hydrolysis of glucose-6-P and glycerol-P was taken as the measure of glucose-6-phosphatase activity. The activity was much higher in the hypothalamus from ob ob mice versus their lean littermates. Activity was undetected in the cortex. These findings raise the possibility that a defect in the regulation of glucose-6-phosphatase activity in a portion of the hypothalamus may relate to the mechanism underlying obesity in the ob ob mouse. However, obese gene product administration to ob ob mice, while reducing the body weight, did not alter the glucose-6-phosphatase activity.
