Optogenetic Stimulation of Basal Forebrain Parvalbumin Neurons Activates the Default Mode Network and Associated Behaviors
Optogenetic Stimulation of Basal Forebrain Parvalbumin Neurons Activates the Default Mode Network and Associated Behaviors
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DOI：
10.1016/j.celrep.2020.108359
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发表时间：
2020-11-10
期刊：
影响因子：
8.8
通讯作者：
Rainer, Gregor
中科院分区：
文献类型：
--
作者：
Lozano-Montes, Laura;Dimanico, Marta;Rainer, Gregor
基底前脑（BF）的激活与注意力、觉醒和外部世界皮层表征的增强有关。此外，BF还参与了默认模式网络（DMN）及相关行为的调节。在这里，我们提供了BF在DMN调节中的作用的因果证据，强调了小白蛋白（PV） gaba能神经元的突出作用。BF - PV神经元的光遗传激活可靠地驱动动物产生类似dmn的行为，而对记忆编码没有影响。相比之下，BF电刺激可增强记忆性能并增加dmn样行为。BF刺激对BF和ACC的肽调节有相关影响，增强了与梳理行为和记忆功能相关的肽，支持BF在DMN调节中的关键作用。我们认为，除了增强注意功能外，BF还包含一个包含PV gaba能神经元的网络，该网络可促进与DMN相关的自我导向行为。
Activation of the basal forebrain (BF) has been associated with increased attention, arousal, and a heightened cortical representation of the external world. In addition, BF has been implicated in the regulation of the default mode network (DMN) and associated behaviors. Here, we provide causal evidence for a role of BF in DMN regulation, highlighting a prominent role of parvalbumin (PV) GABAergic neurons. The optogenetic activation of BF PV neurons reliably drives animals toward DMN-like behaviors, with no effect on memory encoding. In contrast, BF electrical stimulation enhances memory performance and increases DMN-like behaviors. BF stimulation has a correlated impact on peptide regulation in the BF and ACC, enhancing peptides linked to grooming behavior and memory functions, supporting a crucial role of the BF in DMN regulation. We suggest that in addition to enhancing attentional functions, the BF harbors a network encompassing PV GABAergic neurons that promotes self-directed behaviors associated with the DMN.