Human cytomegalovirus polypeptides stimulate neutralizing antibody in vivo.
Human cytomegalovirus polypeptides stimulate neutralizing antibody in vivo.
复制标题
人巨细胞病毒多肽在体内刺激中和抗体。
DOI：
10.1016/0042-6822(85)90215-6
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发表时间：
1985
期刊：
影响因子：
3.7
通讯作者：
Merigan,TC
中科院分区：
文献类型：
--
作者：
Rasmussen,L;Mullenax,J;Nelson,M;Merigan,TC
至少三种人巨细胞病毒多肽是病毒中和抗体的靶点;一种分子量为86，000的单一蛋白质（p86）和两种分子量为130，000和55，000的免疫共沉淀蛋白质（p130/55）。这些多肽已被分离的免疫亲和层析和测试豚鼠的免疫原性。用p86和p130/55免疫后检测到中和抗体。对p130/55而不是p86的超免疫血清依赖于豚鼠补体的病毒中和作用。
At least three human cytomegalovirus polypeptides are targets for virus neutralizing antibody; a single protein of 86,000 molecular weight (p86) and two coimmunoprecipitating proteins of 130,000 and 55,000 molecular weight (p130/55). These polypeptides have been isolated by immunoaffinity chromatography and tested for immunogenicity in guinea pigs. Neutralizing antibody was detected after immunization with both p86 and p130/55. Hyperimmune sera to p130/55, but not p86, were dependent upon guinea pig complement for virus neutralization.