Inorganic chemical biology: from small metal complexes in biological systems to metalloproteins.
Inorganic chemical biology: from small metal complexes in biological systems to metalloproteins.
复制标题
无机化学生物学：从生物系统中的小金属配合物到金属蛋白。
DOI：
10.1016/j.cbpa.2008.03.008
复制
发表时间：
2008
影响因子：
7.8
通讯作者：
Meggers,Eric
中科院分区：
文献类型：
--
作者：
David,SheilaS;Meggers,Eric
对化学生物学的定义往往是不同的，这取决于提供定义的科学家的观点。事实上，对一些人来说，化学生物学是一个宽泛的术语，涉及使用化学方法和技术研究生物学，以及利用生物技术制造新分子和研究化学(1)。化学生物学也经常被定义为使用小分子来揭示生物学的错综复杂(2)。无机化学和化学生物学在哪里相交？？无机化学和生物学之间的界面是丰富的，可以追溯到几个世纪(3，4)。最近，这个领域被称为生物无机化学。生物无机化学的核心是研究金属蛋白和金属酶中的金属位置(3)。合成化学是化学生物学的重要组成部分，已被生物无机化学家用来制作蛋白质中金属中心的小分子光谱和功能模型。此外，利用小分子研究生物学也适用于无机络合物。事实上，无机络合物已经并将继续被用于研究和影响生物过程，这种方法可以追溯到化学和生物混合的早期(4)。显然，无论使用什么标签，无机化学和生物学之间的研究继续蓬勃发展。本期《化学生物学的最新观点》侧重于《生物无机化学》或《无机化学生物学》，对一系列不同的主题进行了综述，提供了这一广泛研究领域中一些有趣的新发现的快照。Bruijnincx和Sadler概述了具有抗癌活性的金属络合物和有机金属试剂的应用新进展。DNA仍然是金属抗癌药物最重要的靶点。在顺铂临床成功的刺激下，铂化合物的靶向递送和前药物激活策略已经被开发出来。一系列Ru和Os半夹心配合物显示出良好的抗癌性能，并允许比铂配合物有更多的配体调节。单核和多核金属络合物正在利用与DNA双链、四链结构和其他二级结构的非配位相互作用。蛋白质作为金属络合物的非传统靶标正变得越来越重要，要么是通过将金属用作
What defines Chemical Biology is often different depending on the vantage point of the scientist offering up the definition. Indeed, to some, chemical biology is a broad term relating to the use of chemical approaches and techniques to study biology and the harnessing of biological techniques to make new molecules and study chemistry (1). Chemical biology is also often defined in terms of the use of small molecules to reveal the intricacies of biology (2). Where does inorganic chemistry intersect with chemical biology?? The interface between inorganic chemistry and biology has been a rich one dating back several centuries (3, 4). In more recent times, this field has been referred to as bioinorganic chemistry. The core of bioinorganic chemistry has focused on the study of metal sites in metalloproteins and metalloenzymes (3). Synthetic chemistry, an important component of chemical biology, has been used by bioinorganic chemists to make small molecule spectroscopic and functional models of metal sites in proteins. In addition, the use of small molecules to study biology also applies to inorganic complexes. Indeed, inorganic complexes have and continue to be used to investigate and influence biological processes, and such approaches trace back to the early times of mixing of chemistry and biology (4). Clearly, regardless of the label used, research at the interface between inorganic chemistry and biology continues to thrive. In this issue of Current Opinions in Chemical Biology focusing on “Bioinorganic Chemistry” or “Inorganic Chemical Biology” a diverse set of topics are reviewed that provides a snapshot of some of the interesting new findings in this broad research area. Specifically, an emphasis has been placed on small molecule inorganic complexes, as probes and that may occur naturally.Bruijnincx and Sadler give an overview of new innovative developments for the use of metal complexes and organometallic agents with anticancer activities. DNA remains the most important target for metal-based anticancer drugs. Stimulated by the clinical success of cisplatin, targeted delivery and prodrug activation strategies of platinum complexes have been developed. A family of ruthenium and osmium half-sandwich complexes show promising anticancer properties and allow more ligand tuning than platinum complexes. Noncoordinative interactions with DNA duplexes, quadruplex structures and other secondary structures are being exploited by mono-and polynuclear metal complexes. Proteins are gaining importance as nontraditional targets for metal complexes either by using the metal as a