The Altered Somatic Brain Network in State Anxiety
The Altered Somatic Brain Network in State Anxiety
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DOI：
10.3389/fpsyt.2019.00465
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发表时间：
2019-07-01
影响因子：
4.7
通讯作者：
Zhang, Hongxing
中科院分区：
文献类型：
--
作者：
Li, Xianrui;Zhang, Meng;Zhang, Hongxing
高度焦虑的人常常表现出过度的情绪唤起、躯体唤起以及精神疾病的特征。先前的研究广泛调查了高度焦虑症患者的情绪和认知偏差，但忽视了与躯体唤醒相关的自发大脑活动和功能连接。在这项研究中，我们调查了患有状态焦虑的非临床健康人群的状态焦虑与体感皮层自发大脑活动之间的关系。此外，我们还探索了体感皮层的功能连接。我们发现，状态焦虑与躯体相关大脑区域的低频波动（ALFF）幅度呈正相关，包括右侧中央后回（体感皮层）和右侧中央前回（躯体运动皮层）。此外，我们发现状态焦虑与中央后回和左侧小脑回之间的连接呈正相关，而状态焦虑与中央后回和大脑区域（包括左下额皮质和左内侧上额皮质）之间的连接呈负相关。这些结果揭示了焦虑个体的身体循环与健康人群的状态焦虑之间的关联，揭示了体脑区域在焦虑症状中的重要性，为进一步研究焦虑提供了新的视角。
Highly anxious individuals often show excessive emotional arousal, somatic arousal, and characteristics of mental illness. Previous researches have extensively investigated the emotional and cognitive biases of individuals with high anxiety, but overlooked the spontaneous brain activity and functional connections associated with somatic arousal. In this study, we investigated the relationship between state anxiety and the spontaneous brain activity of the somatosensory cortex in a non-clinical healthy population with state anxiety. Furthermore, we also explored the functional connections of the somatosensory cortex. We found that state anxiety was positively correlated with the amplitude of low-frequency fluctuations (ALFFs) of somatic related brain regions, including the right postcentral gyrus (somatosensory cortex) and the right precentral gyrus (somatic motor cortex). Furthermore, we found that state anxiety was positively correlated with the connections between the postcentral gyrus and the left cerebellum gyrus, whereas state anxiety was negatively correlated with the connectivity between the postcentral gyrus and brain regions including the left inferior frontal cortex and left medial superior frontal cortex. These results revealed the association between the anxious individuals' body-loop and state anxiety in a healthy population, which revealed the importance of somatic brain regions in anxiety symptoms and provided a new perspective on anxiety for further study.