Recent advances in engineering topography mediated antibacterial surfaces.
Recent advances in engineering topography mediated antibacterial surfaces.
复制标题
DOI：
10.1039/c5nr04156b
复制
发表时间：
2015-10-14
期刊：
影响因子：
6.7
通讯作者：
Chatterjee K
中科院分区：
文献类型：
--
作者：
Hasan J;Chatterjee K
介绍了形貌驱动抗菌表面的最新研究进展。综述了微结构抗生物污损和纳米结构杀菌表面。细菌细胞粘附和定殖材料表面导致生物膜形成的趋势是许多不同应用（包括与生物医学装置和产品相关的微生物感染）的根本挑战。虽然，细菌附着在表面已被广泛研究，在过去，表面形貌对细菌-材料相互作用的影响很少受到关注，直到最近。本文综述了近年来基于表面形貌的抗菌表面工程方法的研究进展。自然界中抗菌表面的仿生是一种流行的策略。尽管该领域的早期努力旨在使细胞附着最小化，但最近的努力集中在开发杀菌表面上。然而，并不是所有这样的形貌介导的杀菌表面都必须是细胞相容性的，因此强调需要在该领域继续努力研究，以开发用于可植入生物医学应用的抗菌和细胞相容性表面。本文简要综述了拓扑结构介导的抗菌表面这一新兴领域的当前策略和挑战。
Recent advances in the field of topography driven antibacterial surfaces are presented. Micro-structured antibiofouling and nano-structured bactericidal surfaces are reviewed. The tendency of bacterial cells to adhere and colonize a material surface leading to biofilm formation is a fundamental challenge underlying many different applications including microbial infections associated with biomedical devices and products. Although, bacterial attachment to surfaces has been extensively studied in the past, the effect of surface topography on bacteria–material interactions has received little attention until more recently. We review the recent progress in surface topography based approaches for engineering antibacterial surfaces. Biomimicry of antibacterial surfaces in nature is a popular strategy. Whereas earlier endeavors in the field aimed at minimizing cell attachment, more recent efforts have focused on developing bactericidal surfaces. However, not all such topography mediated bactericidal surfaces are necessarily cytocompatible thus underscoring the need for continued efforts for research in this area for developing antibacterial and yet cytocompatible surfaces for use in implantable biomedical applications. This mini-review provides a brief overview of the current strategies and challenges in the emerging field of topography mediated antibacterial surfaces.