A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
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DOI：
10.1016/j.ehj.2003.07.001
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发表时间：
2003-10-01
影响因子：
39.3
通讯作者：
Gaffney, D
中科院分区：
文献类型：
--
作者：
Freeman, DJ;Samani, NJ;Gaffney, D
目的在苏格兰西部冠状动脉预防研究（WOSCOPS）中检测胆固醇酯转运蛋白（CETP）基因多态性与心血管事件风险之间的关系，以及任何相关性是否可以通过影响高密度脂蛋白（HDL）水平或低密度脂蛋白（LDL）大小来解释。方法和结果病例组（n=498）和对照组（n=1108）进行Taq 1B、C（-631）A、C（-629）A、1405 V和D442 G CETP多态性分型。与B1 B1纯合子相比，Taq 1B 2等位基因纯合子（B2 B2）具有30%的心血管事件风险降低（优势比[OR] 0.70，CI 95，0.51-0.96，P=0.03）。在多变量分析中纳入HDL或LDL直径仅略微减弱了相关性。非吸烟者，但不是吸烟者，显示出剂量依赖性的风险与TdqlB基因型。治疗获益在B1 B1（OR 0.71，普伐他汀vs安慰剂）、B1 B2（OR 0.68）和B2 B2（OR 0.61）个体中无显著差异。其他CETP基因多态性与心血管疾病风险无显著相关性。单倍型分析没有添加到个人polymorphis.Conclusion的信息CETP TaqlB基因型和心血管疾病的风险之间的关联主要是在非吸烟者，是不完全解释的影响HDL水平或LDL大小，普伐他汀治疗的好处是不受此多态性。(C)2003年由Elsevier Ltd代表欧洲心脏病学会出版。
Aim The association of cholesteryl ester transfer protein (CETP) gene polymorphisms with risk of a cardiovascular event and whether any association was explained by an influence on high-density lipoprotein (HDL) levels or tow-density lipoprotein (LDL) size was tested in the West of Scotland Coronary Prevention Study (WOSCOPS). Gene-smoking and gene-treatment interactions were investigated.Methods and results Cases (n=498) and controls (n=1108) were typed for TaqlB, C(-631)A, C(-629)A, 1405V and D442G CETP polymorphisms. Homozygotes for the TaqlB2 allele (B2B2) had a 30% reduced risk of a cardiovascular event (odds ratio [OR] 0.70, CI95, 0.51-0.96, P=0.03) compared to B1B1 homozygotes. Inclusion of HDL or LDL diameter in multivariate analysis only marginally attenuated the relationships. Non-smokers, but not smokers, showed a dose-dependent association of risk with TdqlB genotype. Treatment benefit was not significantly different in B1B1 (OR 0.71, pravastatin vs placebo), B1B2 (OR 0.68) and B2B2 (OR 0.61) individuals. The other CETP polymorphisms studied had no significant association with cardiovascular risk. Haplotype analysis did not add to the information given by the individual polymorphisms.Conclusion The association between CETP TaqlB genotype and cardiovascular risk is primarily in non-smokers, is not fully explained by effects on HDL levels or LDL size, and the benefit of pravastatin treatment was not influenced by this polymorphism. (C) 2003 Published by Elsevier Ltd on behalf of The European Society of Cardiology.