Novel and Direct Transformation of Methyl Ketones or Carbinols to Primary Amides by Employing Aqueous Ammonia
Novel and Direct Transformation of Methyl Ketones or Carbinols to Primary Amides by Employing Aqueous Ammonia
复制标题
利用氨水将甲基酮或甲醇直接转化为伯酰胺
DOI：
10.1021/ol901250c
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发表时间：
2009-09-03
期刊：
影响因子：
5.2
通讯作者：
Wu, Anxin
中科院分区：
文献类型：
--
作者：
Cao, Liping;Ding, Jiaoyang;Wu, Anxin
开发了一种新的芳基、杂芳基、乙烯基或乙炔基甲基酮或甲醇直接转化为相应伯胺的方法。在水介质中，碘-NH3中心点状H2O体系对该反应是有效的，得到了预期的产物，产率较高。首次提出了这类反应的串联Lieben-Haller-Bauer反应机理。
A novel and direct transformation of aryl, heteroaryl, vinyl, or ethynyl methyl ketones or carbinols to corresponding primary amides has been developed. An iodine-NH3 center dot H2O system was proven to be efficient for this reaction and afforded the expected products with good yields in aqueous media. A tandem Lieben-Haller-Bauer reaction mechanism was involved in this type of reaction and is proposed for the first time.