Pulsed cavitational ultrasound therapy for controlled tissue homogenization
Pulsed cavitational ultrasound therapy for controlled tissue homogenization
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DOI：
10.1016/j.ultrasmedbio.2005.09.005
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发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Fowlkes, JB
中科院分区：
文献类型：
--
作者：
Parsons, JE;Cain, CA;Fowlkes, JB
研究了声学控制空化介导的组织均质化在体外形成损伤的程度的方法。这些结果可以指导潜在的治疗程序，主要通过机械破坏引起损伤，从而避免与热消融方式相关的限制。使用由高振幅脉冲（22 MPa P-r）与可变振幅“维持”脉冲（例如，6.9 MPa P-r），其旨在提供足够的声输入以维持主脉冲之间的空化活动，但仅略微增加空间峰值时间平均强度。使用适度的时间平均强度（例如，I-SPTA约200 W/cm（2）），产生约0.5 cm（3）的损伤，由匀浆组成，可以冲洗掉以显示光滑的腔。在一个给定的病变中的匀浆的患病率是敏感的脉冲重复频率和维持脉冲幅度，这表明存在最佳的声学参数，主要是通过机械扰动产生均质化病变。
Methods were investigated to acoustically control the extent to which cavitation-mediated tissue homogenization is responsible for lesion formation in vitro. These results may guide potential therapeutic procedures that induce damage predominantly via mechanical disruption and, thereby, avoid limitations associated with thermal ablative modalities. Porcine myocardium was insonified at 750 kHz using pulse sequences consisting of high-amplitude pulses (22 MPa P-r) interleaved with variable-amplitude "sustaining" pulses (e.g., 6.9 MPa P-r), which were intended to provide sufficient acoustic input to maintain cavitation activity between primary pulses, but to increase the spatial peak temporal average intensity only marginally. Using modest temporal-average intensities (e.g., I-SPTA approximate to 200 W/cm(2)), approximate to 0.5 cm(3) lesions were produced consisting of homogenate that could be irrigated away to reveal smooth cavities. The prevalence of homogenate in a given lesion was sensitive to both pulse-repetition frequency and sustaining pulse amplitude, suggesting the existence of optimum acoustic parameters for producing homogenized lesions largely via mechanical perturbation.