Diversity of biomedical applications of acoustic radiation force
Diversity of biomedical applications of acoustic radiation force
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DOI：
10.1016/j.ultras.2009.10.001
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发表时间：
2010-02-01
期刊：
影响因子：
4.2
通讯作者：
Sarvazyan, Armen
中科院分区：
文献类型：
--
作者：
Sarvazyan, Armen
本手稿是 ICU'2009 上发表的关于声辐射力生物医学应用论文的摘要，重点是微流体、生物技术、生物传感器和骨骼系统评估中的新兴应用。在对辐射力当前和预计应用的简要概述中，没有给出说明特定应用的实验的详细描述，因为这将导致一篇截然不同且更长的论文。考虑了声辐射力产生的各种机制及其生物医学应用。这些机制包括： (a) 由于吸收和散射而导致传播波的能量密度发生变化； (b) 声驻波能量密度的空间变化； (c) 来自内含物、墙壁或其他界面的反射； (d) 传播速度的空间变化。辐射力生物医学应用最广泛的领域与医学诊断、评估生物组织和液体的粘弹性特性，特别是弹性成像有关。另一个积极探索的领域与在驻超声波场中操纵生物细胞和颗粒有关。超声辐射力的潜在生物医学应用有几个尚未探索的领域。超声辐射力的生物医学应用的一个有前途的领域是微流体和各种生物技术应用中微量液体的搅拌和混合，其中扩散速率是限制感兴趣过程效率的主要因素。描述了一种称为“扫频法”的新技术，该技术基于利用驻声波中的辐射力来微搅拌液体。考虑了超声辐射力在骨骼系统评估中的潜在应用，而传统的骨超声测量法不适用。 (C) 2009 Elsevier B.V. 保留所有权利。
This manuscript is a summary of the paper presented at the ICU'2009 on biomedical applications of acoustic radiation force with emphasis on emerging applications in microfluidics, biotechnology, biosensors and assessment of the skeletal system. In this brief overview of current and projected applications of radiation force, no detailed description of the experiments illustrating particular applications are given as this would result in a far different and longer paper. Various mechanisms of acoustic radiation force generations and their biomedical applications are considered. These mechanisms include: (a) change in the density of energy of the propagating wave due to absorption and scattering; (b) spatial variations of energy density in standing acoustic waves; (c) reflection from inclusions, walls or other interfaces; and (d) spatial variations in propagation velocity. The widest area of biomedical applications of radiation force is related to medical diagnostics, to assessing viscoelastic properties of biological tissues and fluids, and specifically to elasticity imaging. Another actively explored area is related to manipulation of biological cells and particles in standing ultrasonic wave fields.There are several poorly explored areas of potential biomedical applications of ultrasound radiation force. A promising area of biomedical application of ultrasound radiation force is stirring and mixing of microvolumes of liquids in microfluidics and in various biotechnological application where diffusion rate is the main factor limiting the efficiency of the process of interest. A new technique, called "swept frequency method", based on the use of radiation force in the standing acoustic wave for microstirring of liquids is described. The potential applications of the ultrasound radiation force for assessment of skeletal system, where conventional bone ultrasonometry are inapplicable are considered. (C) 2009 Elsevier B. V. All rights reserved.