Neoplastic human fibroblast proteins are related to epidermal growth factor precursor.
Neoplastic human fibroblast proteins are related to epidermal growth factor precursor.
复制标题
肿瘤性人成纤维细胞蛋白与表皮生长因子前体有关。
DOI：
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发表时间：
1984
影响因子：
11.1
通讯作者：
J. Leavitt
中科院分区：
文献类型：
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作者：
S. Burbeck;G. Latter;E. Metz;J. Leavitt
我们报道了两个多肽p788和p789的氨基酸组成。这些多肽是人成纤维细胞肿瘤转化的可靠标记。它们的成分中含有丰富的半胱氨酸和丝氨酸。由于最近报道的小鼠表皮生长因子前体（prepro-EGF）的氨基酸序列也富含这两种氨基酸，并且由于p788和p789作为肿瘤转化的标记物的作用与表皮生长因子在转化中发挥一定作用的事实是一致的，我们研究了p788和p789与prepro-EGF有关的假设。我们将p788的氨基酸组成与合适长度的pre - egf所有可能的内部结构域的氨基酸组成进行了比较。我们发现p788的组成与pre - egf的残基630-880非常相似。这种相似性足以支持其反映氨基酸序列同源性的结论。
We report the amino acid composition of two polypeptides, p788 and p789. These polypeptides are reliable markers for neoplastic transformation in human fibroblasts. Their compositions are unusually rich in cysteine and serine. Because the recently reported amino acid sequence of mouse epidermal growth factor precursor (prepro-EGF) is also rich in those two amino acids and because the role of p788 and p789 as markers for neoplastic transformation is consistent with the fact that epidermal growth factor has been shown to play some role in transformation, we investigated the hypothesis that p788 and p789 are related to prepro-EGF. We compared the amino acid composition of p788 with that of all possible interior domains of prepro-EGF of appropriate length. We found that the composition of p788 is remarkably similar to that of residues 630-880 of prepro-EGF. The similarity is sufficiently strong to support the conclusion that it reflects amino acid sequence homology.