High prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
High prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
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DOI：
10.1210/jc.2006-1668
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发表时间：
2006-12-01
影响因子：
5.8
通讯作者：
Beckers, Albert
中科院分区：
文献类型：
--
作者：
Daly, Adrian F.;Rixhon, Martine;Beckers, Albert
内容：患病率数据对于评估疾病对卫生保健系统的负担非常重要;垂体腺瘤患病率数据非常缺乏。目的：本研究的目的是在明确定义的人群中测量临床相关垂体腺瘤的患病率。设计：这是一项在比利时列日省的三个地区进行的横断面、密集的病例发现研究，测量截至2005年9月30日的垂体腺瘤患病率。设置：本研究在专科和全科医生患者人群、转诊医院和研究中心进行。方法：使用邮政编码精确划定列日省三个人口统计学和地理上不同的地区。招募了这些地区的医生，并确定了在他们护理下的垂体腺瘤患者。诊断确认后检索的临床，激素，放射学和病理学数据;充分的人口统计学和治疗的后续数据收集在所有cases.Results：68例临床相关的垂体腺瘤被确定在人口71,972人;平均（+/- SD）患病率为每10万人94 +/- 19.3例（95%置信区间，72.2 - 115.8）。本组67.6%为女性，诊断时平均年龄为40.3岁; 42.6%患有大腺瘤，55.9%接受了手术。催乳素瘤包括66%的组，其余的非分泌性肿瘤（14.7%），生长激素瘤（13.2%），或库欣病（5.9%）; 20.6%有hypopituitaris.Conclusion：在研究人群中的垂体腺瘤的患病率（一例在1064人）超过3.5-5倍，以前报道。这种增加的患病率可能有重要的意义时，优先考虑资金的研究和治疗垂体腺瘤。
Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce.Objective: The objective of the study was to measure the prevalence of clinically relevant pituitary adenomas in a well-defined population.Design: This was a cross-sectional, intensive, case-finding study performed in three regions of the province of Liege, Belgium, to measure pituitary adenoma prevalence as of September 30, 2005.Setting: The study was conducted in specialist and general medical practitioner patient populations, referral hospitals, and investigational centers.Methods: Three demographically and geographically distinct districts of the province of Liege were delineated precisely using postal codes. Medical practitioners in these districts were recruited, and patients with pituitary adenomas under their care were identified. Diagnoses were confirmed after retrieval of clinical, hormonal, radiological, and pathological data; full demographic and therapeutic follow-up data were collected in all cases.Results: Sixty-eight patients with clinically relevant pituitary adenomas were identified in a population of 71,972 individuals; the mean (+/- SD) prevalence was 94 +/- 19.3 cases per 100,000 population (95% confidence interval, 72.2 to 115.8). The group was 67.6% female and had a mean age at diagnosis of 40.3 yr; 42.6% had macroadenomas and 55.9% underwent surgery. Prolactinomas comprised 66% of the group, with the rest having nonsecreting tumors (14.7%), somatotropinomas (13.2%), or Cushing's disease (5.9%); 20.6% had hypopituitarism.Conclusion: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5-5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas.