The “Intraepidermal Epithelioma” Revisited: Immunohistochemical Study of the Borst–Jadassohn Phenomenon
The “Intraepidermal Epithelioma” Revisited: Immunohistochemical Study of the Borst–Jadassohn Phenomenon
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重温“表皮内上皮瘤”：Borst-Jadassohn 现象的免疫组织化学研究
DOI：
10.1097/dad.0b013e3181fe6f90
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Jean Kanitakis
中科院分区：
文献类型：
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作者：
V. Lora;B. Chouvet;Jean Kanitakis
人们对所谓的 Borst-Jadassohn 表皮内上皮瘤的真正性质知之甚少。这是否代表一种独特的肿瘤或不同实体共有的形态学现象[Borst-Jadassohn现象（BJP）]一直存在争议。到目前为止，还没有进行详细的免疫组织化学研究来解决这个问题。我们研究的目的是进一步了解 Borst-Jadassohn/BJP 表皮内上皮瘤的发病机制。研究显示 BJP 的肿瘤[主要是克隆性脂溢性角化病 (cSK) 和克隆性 Bowen 病 (cBD)]，并与典型（非克隆）对应肿瘤进行比较。 cSK、cBD、单纯性汗棘皮瘤 (HS) 和毛孔癌 (PC) 中的细胞巢显示表皮生长因子受体 (EGF-R)、Ki-67、p63 和 p53 的强表达。克隆 SK 和 HS（但不包括克隆 BD 或 PC）的细胞巢表达角蛋白 5/6。所有病变巢内E-钙粘蛋白的表达和CD1a+朗格汉斯细胞的数量均减少，而所有病变巢内的黑素细胞均增加。角蛋白 7 和 19 在任何病变中均不表达。显示 BJP 的肿瘤表现出一些免疫组织化学差异，表明它们代表不同的实体。然而，它们都在表皮内角质形成细胞巢内表现出 EGF-R 的强表达，表明上皮生长因子途径在 BJP 的发育中发挥作用。
The true nature of the so-called intraepidermal epithelioma of Borst-Jadassohn is poorly understood; whether this represents a distinct tumor or a morphological phenomenon [Borst-Jadassohn phenomenon (BJP)] shared by different entities has been debated. So far, no detailed immunohistochemical studies have been performed to address this issue. The aim of our study was to get further insight into the pathogenesis of the intraepidermal epithelioma of Borst-Jadassohn/BJP. Tumors showing the BJP [mainly clonal seborrheic keratoses (cSK) and clonal Bowen disease (cBD)] were studied and compared with typical (nonclonal) counterparts. Cell nests in cSK, cBD, hidroacanthoma simplex (HS), and porocarcinoma (PC) showed strong expression of epidermal growth factor-receptors (EGF-R), Ki-67, p63, and p53. Cell nests of clonal SK and HS (but not of clonal BD or PC) expressed keratin 5/6. The expression of E-cadherin and the number of CD1a+ Langerhans cells were reduced within the nests of all lesions, whereas melanocytes were increased in all of them. Keratins 7 and 19 were not expressed in any of the lesions. Tumors showing the BJP exhibit some immunohistochemical differences, suggesting that they represent separate entities. However, they all show strong expression of EGF-R within intraepidermal keratinocyte nests, suggesting that the epithelial growth factor pathway plays a role in the development of the BJP.