Prevalence of CKD in Northeastern Italy: Results of the INCIPE Study and Comparison with NHANES
Prevalence of CKD in Northeastern Italy: Results of the INCIPE Study and Comparison with NHANES
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DOI：
10.2215/cjn.02400310
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发表时间：
2010-11-01
影响因子：
9.8
通讯作者：
Lupo, Antonio
中科院分区：
文献类型：
--
作者：
Gambaro, Giovanni;Yabarek, Tewoldemedhn;Lupo, Antonio
背景和目标：足够的动力研究，以调查慢性肾脏病的患病率是很少的，不包括southern European.Design，设置，参与者，和测量：对于INCIPE研究，6200名白人患者>= 40岁，随机选择在东北部意大利在2006年。实验室测定集中进行。测定尿中白蛋白/肌酐比值和根据校准肌酐（SCr）估计的GFR。2001年至2006年NHANES调查进行了比较。结果：CKD的患病率为13.2%，在东北部（NE）意大利（年龄和性别标准化为美国2007年高加索人口）。美国白人中CKD的患病率较高（20.3%），主要差异为CKD 3。CKD的风险因素在美国比在意大利更普遍。使用CKD 3a和3b分期，CKD患病率在NE意大利（8.5%）和美国（12.8%）下降。结论：CKD患病率在NE意大利较高，但低于美国。意大利NE与美国CKD患病率的差异很大一部分是由于CKD 3的患病率不同。来自美国的人中一些肾脏风险因素的较高患病率部分解释了两个人群中CKD问题的不同维度。Clin J Am Soc Nephrol 5：1946-1953，2010. doi：10.2215/CJN.02400310
Background and objectives: Sufficiently powered studies to investigate the CKD prevalence are few and do not cover southern Europe.Design, setting, participants, & measurements: For the INCIPE study, 6200 Caucasian patients >= 40 years old were randomly selected in northeastern Italy in 2006. Laboratory determinations were centralized. The albumin to creatinine ratio in urine and estimated GFR from calibrated creatinine (SCr) were determined. A comparison with 2001 through 2006 NHANES surveys was performed.Results: Prevalence of CKD was 13.2% in northeastern (NE) Italy (age and gender standardized to the U.S. 2007 Caucasian population). Prevalence of CKD in U.S. Caucasians is higher (20.3%), the major difference being in CKD 3. Risk factors for CKD are more prevalent in the United States than in Italy. With use of CKD 3a and 3b stages, CKD prevalence decreased in NE Italy (8.5%) and in the United States (12.8%).Conclusions: The prevalence of CKD is high in NE Italy, but lower than that in the United States. A large part of the difference in CKD prevalence in NE Italy versus that in the United States is due to the different prevalence of CKD 3. The higher prevalence of a number of renal risk factors in persons from the United States explains in part the different dimensions of the CKD problem in the two populations. Clin J Am Soc Nephrol 5: 1946-1953, 2010. doi: 10.2215/CJN.02400310