MODELING FUNCTIONAL DECLINE OVER TIME IN SPORADIC INCLUSION BODY MYOSITIS
MODELING FUNCTIONAL DECLINE OVER TIME IN SPORADIC INCLUSION BODY MYOSITIS
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DOI：
10.1002/mus.25373
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发表时间：
2017-04-01
期刊：
影响因子：
3.4
通讯作者：
Lowes, Linda P.
中科院分区：
文献类型：
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作者：
Alfano, Lindsay N.;Yin, Han;Lowes, Linda P.
简介：根据患者的独特特征对疾病进展提出个性化建议或预期的能力对于散发性包涵体肌炎 (sIBM) 具有重要的应用价值。方法：55 名 sIBM 受试者在 2 次研究访问中完成了一系列力量和功能结果。这些被用来开发 sIBM 患者疾病进展的数学模型，用于临床和研究环境。结果：6 分钟步行测试 (6MWT) 距离每年平均下降 27.5 米 (12%)。预测 6MWT 的重要因素是膝关节伸展和跖屈力量以及体重，而从椅子上站立的能力则受到肘部伸展力量的影响。走上路边受到患者诊断时年龄和膝关节伸展的影响。开发了预测 sIBM 功能衰退的统计模型。结论：统计模型有助于解释影响 sIBM 步行能力和其他功能活动下降的复杂因素。
Introduction: The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM). Methods: Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. These were used to develop mathematical models of disease progression in patients with sIBM for use in clinical and research settings. Results: The 6-minute walk test (6MWT) distance declined by an average of 27.5 meters (12%) per year. Significant factors that predict 6MWT were knee extension and plantarflexion strength and body weight, whereas the ability to stand from a chair was impacted by elbow extension strength. Stepping up on a curb was influenced by the patient's age at diagnosis and by knee extension. Statistical models to predict functional decline in sIBM were developed. Conclusion: Statistical models help explain the complex factors that influence decreased walking ability and other functional activities in sIBM.