Kinetics of Somatostatin Receptor Migration in Isolated Pancreatic Islets
Kinetics of Somatostatin Receptor Migration in Isolated Pancreatic Islets
复制标题
离体胰岛中生长抑素受体迁移动力学
DOI：
10.2337/diab.31.5.467
复制
发表时间：
1982
期刊：
影响因子：
7.7
通讯作者：
K. Sussman
中科院分区：
文献类型：
--
作者：
B. Draznin;J. Leitner;K. Sussman
Eighty-seven percent of the total cellular pool of somatostatin (SRIF) receptors in pancreatic islets are located intracellularly. Upon glucose stimulation (300 mg/dl) of insulin release, 8–15% of intracellular SRIF receptors are translocated to the plasma membrane. Affinity of SRIF receptors does not change during their migration and the total cellular pool of receptors remains constant. With prolonged glucose stimulation, surface membrane somatostatin receptor concentration reaches a maximum level at 60 min.
