The consumption of tobacco, alcohol, and coffee in Caucasian Male twins: A multivariate genetic analysis
The consumption of tobacco, alcohol, and coffee in Caucasian Male twins: A multivariate genetic analysis
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DOI：
10.1016/s0899-3289(96)90055-3
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Cardon, LR
中科院分区：
文献类型：
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作者：
Swan, GE;Carmelli, D;Cardon, LR
尽管流行病学研究表明，吸烟、饮酒和咖啡之间存在一致的协变，但大多数先前的行为遗传学研究都确定了遗传和环境影响的作用，就好像这些物质的消费是相互独立的。在这项研究中，我们使用多变量结构方程模型来确定在173个同卵和183个异卵男性双胞胎对中所观察到的吸烟和饮酒以及喝咖啡之间的相关性中的遗传和环境重叠（M年龄= 59岁;年龄范围= 52-66岁），他们参加了国家心脏、肺和血液研究所双胞胎研究的随访心血管检查。与联合使用这些物质的假设心理神经发生倾向一致，拟合这些数据的最简约模型确定了一个共同的遗传潜在因素，该因素与该队列中吸烟、饮酒和咖啡使用之间的观察到的关联有关。这个因素，在这里被称为多物质使用，强调了遗传影响对同一个体中这些行为的聚集的作用。
Despite the fact that epidemiologic studies demonstrate a consistent covariation between the use of tobacco, alcohol, and coffee, most previous behavioral genetic studies have determined the contribution of genetic and environmental influences as if the consumption of these substances occurred independently of each other. In this study, we used multivariate structural equation modeling to determine the genetic and environmental overlap in the observed correlations between tobacco smoking and alcohol and coffee drinking in 173 monozygotic and 183 dizygotic male twin pairs (M age = 59 years; range = 52-66 years) who participated in a follow-up cardiovascular examination of the National Heart, Lung, and Blood Institute's Twin Study. Consistent with hypothesized psychoneurogenetic predispositions for the joint use of these substances, the most parsimonious model fitting these data identified a common genetic latent factor underlying the observed associations between smoking, alcohol, and coffee use in this cohort. This factor, herein called polysubstance use, underscores the role of genetic influence on the clustering of these behaviors in the same individual.