Fibronectin and laminin enhance gingival cell attachment to dental implant surfaces in vitro.
Fibronectin and laminin enhance gingival cell attachment to dental implant surfaces in vitro.
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发表时间：
1995-11
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通讯作者：
J. W. Dean;K. C. Culbertson;A. D'Angelo
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作者：
J. W. Dean;K. C. Culbertson;A. D'Angelo
这项研究的目的是确定生物活性分子层粘连蛋白和纤维连接蛋白在体外是否会影响牙龈细胞与种植体表面的附着。测试了以下植入材料的平方：光滑的、等离子喷涂的和羟基磷灰石涂层的钛。表面涂有等摩尔层粘连蛋白、纤维连接蛋白或牛血清白蛋白。种植体表面的纤维粘连蛋白涂层使牙周成纤维细胞在所有种植体表面的结合力增加2-3倍(P<；.01)，而对上皮细胞的影响较小。层粘连蛋白涂层可使所有种植体表面的牙龈上皮细胞结合力提高三到四倍(P<；.01)，而对成纤维细胞的影响较小。这两种细胞类型对不同的分子表现出不同的偏好，表面粗糙度有一定的影响。
The objective of this study was to determine if the biologically active molecules laminin and fibronectin could influence gingival cell attachment to implant surfaces in vitro. Flat squares of the following implant materials were tested: smooth, plasma-sprayed, and hydroxyapatite-coated titanium. The surfaces were coated with equimolar quantities of either laminin, fibronectin, or bovine serum albumin. Fibronectin coating of implant surfaces resulted in two to three times the enhancement of gingival fibroblast binding on all implant surfaces tested (P < .01), with a lesser effect on epithelial cells. Laminin coating resulted in three to four times the enhancement of gingival epithelial cell binding on all implant surfaces tested (P < .01), with a lesser effect on fibroblasts. The two cell types exhibited distinct preferences for the different molecules tested with the surface roughness having some influence.