Myocardial lineage development.
Myocardial lineage development.
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DOI：
10.1161/circresaha.110.227405
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发表时间：
2010-12-10
影响因子：
20.1
通讯作者：
Kirby ML
中科院分区：
文献类型：
--
作者：
Evans SM;Yelon D;Conlon FL;Kirby ML
心脏的心肌由多个高度特化的心肌谱系组成，包括心室和心房心肌的那些，以及特化的传导系统。在心脏发育过程中，这些谱系中的每一个的规范和成熟是一个高度有序的、持续的过程，涉及多个信号通路及其与转录调控网络的交叉。在这里，我们试图总结和比较我们所知道的规范和成熟的心肌谱系的研究在几个不同的脊椎动物模型系统。到目前为止，大多数研究都集中在早期规范，虽然还有更多的学习，较少的是已知的因素，促进随后成熟的心肌谱系所需的建立功能的成人心脏。
The myocardium of the heart is composed of multiple highly specialized myocardial lineages, including those of the ventricular and atrial myocardium, and the specialized conduction system. Specification and maturation of each of these lineages during heart development is a highly ordered, ongoing process involving multiple signaling pathways and their intersection with transcriptional regulatory networks. Here, we attempt to summarize and compare much of what we know about specification and maturation of myocardial lineages from studies in several different vertebrate model systems. To date, most research has focused on early specification, and while there is still more to learn, less is known about factors that promote subsequent maturation of myocardial lineages required to build the functioning adult heart.