Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice
Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice
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DOI：
10.1007/s11745-006-5117-3
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发表时间：
2006-05-01
期刊：
影响因子：
1.9
通讯作者：
Fernandes, Gabriel
中科院分区：
文献类型：
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作者：
Bhattacharya, Arunabh;Rahman, M. Mizanur;Fernandes, Gabriel
超过一半的美国人口的体重指数为25 kg/m2或更高，这将他们归类为超重或肥胖。肥胖通常与糖尿病、心血管疾病和癌症等合并症有关。CLA和铬已成为主要的膳食补充剂，可降低体重和脂肪量，并增加动物模型的基础代谢率。然而，研究表明，共轭亚油酸诱导小鼠和人类的胰岛素抵抗，而铬改善胰岛素敏感性。因此，我们设计了本研究，以检查CLA和铬的身体组成和胰岛素敏感性的Balb/c小鼠（n = 10/组）模型的高脂肪饮食诱导的肥胖症的联合作用。单独使用CLA可以降低体重、全身脂肪量和内脏脂肪量，而CLA和Cr联合使用可以进一步降低内脏脂肪量。这种作用伴随着CLA喂养和CLA + Cr喂养的小鼠血清瘦素水平降低，以及CLA + Cr喂养的小鼠更高的能量消耗（EE）和氧消耗（OC）。血清葡萄糖，胰岛素，促炎细胞因子，肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6），以及胰岛素抵抗指数（IRI），降低与CLA，而CLA和Cr的组合有显着的影响胰岛素和IL-6的浓度和IRI。总之，CLA + Cr降低了高脂饮食喂养小鼠的体重和脂肪量，这可能与瘦素水平降低以及EE和OC升高有关。
More than half of the U.S. population has a body mass index of 25 kg/m(2) or more, which classifies them as overweight or obese. Obesity is often associated with comorbidities such as diabetes, cardiovascular diseases, and cancer. CLA and chromium have emerged as major dietary supplements that reduce body weight and fat mass, and increase basal metabolic rate in animal models. However, studies show that CLA induces insulin resistance in mice and in humans, whereas Cr improves insulin sensitivity. Hence, we designed the present study to examine the combined effect of CLA and Cr on body composition and insulin sensitivity in a Balb/c mice (n = 10/group) model of high-fat-diet-induced obesity. CLA alone lowered body weight, total body fat mass, and visceral fat mass, the last of which decreased further with the combination of CLA and Cr. This effect was accompanied by decreased serum leptin levels in CLA-fed and CLA + Cr-fed mice, and by higher energy expenditure (EE) and oxygen consumption (OC) in CLA + Cr-fed mice. Serum levels of glucose, insulin, the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), as well as insulin resistance index (IRI), decreased with CLA, whereas CLA and Cr in combination had significant effects on insulin and IL-6 concentrations and IRI. In summary, CLA + Cr decreased body weight and fat mass in high-fat-diet-fed mice, which may be associated with decreased leptin levels and higher EE and OC.