Gestational diabetes the significance of persistent fasting hyperglycemia for the subsequent development of diabetes mellitus
Gestational diabetes the significance of persistent fasting hyperglycemia for the subsequent development of diabetes mellitus
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DOI：
10.1016/j.jdiacomp.2005.05.001
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发表时间：
2006-01-01
影响因子：
3
通讯作者：
Helmink, D
中科院分区：
文献类型：
--
作者：
Cheung, NW;Helmink, D
关于妊娠期糖尿病（GDM）高血糖的时间模式及其对未来糖尿病发展的意义的数据很少。本研究的目的是探讨妊娠期糖尿病孕妇空腹和餐后高血糖与随后糖尿病（DM）发展的关系。有GDM病史的参与者通过医疗记录审查确定，并被邀请进行糖尿病检测。102名参与者参加了这项研究，直到怀孕后8年。29%的患者患有糖尿病，16%的患者葡萄糖耐量受损。预测糖尿病发生的妊娠因素包括BMI、空腹和2小时血糖（GTT）以及胰岛素的使用。我们使用睡前中效胰岛素作为持续空腹高血糖的指标，使用餐时短效胰岛素作为餐后高血糖的标志。与未接受胰岛素治疗的受试者相比，需要睡前胰岛素治疗的受试者的相对风险为6.2（95%CI =2.7-14.1，P
There are little data regarding the temporal pattern of hyperglycaemia during gestational diabetes (GDM) and its significance for the development of future diabetes. The aim of this study was to examine the relationship between fasting and postprandial hyperglycemia in a GDM pregnancy, with the development of subsequent diabetes mellitus (DM). Participants with a history of GDM were identified by a medical records review and invited to be tested for diabetes. One hundred and two participants participated in the study, up to 8 years after their pregnancy. Diabetes had developed in 29%, and 16% had impaired glucose tolerance. Pregnancy factors predictive for the development of diabetes included BMI, the fasting and 2-h BGL on the GTT, and the use of insulin. We used the need for bedtime intermediate-acting insulin as an indicator of persistent fasting hyperglycemia and the need for prandial short-acting insulin as a marker of postprandial hyperglycemia. Compared with participants not treated with insulin, those requiring bedtime insulin had a relative risk of 6.2 (95% CI=2.7-14.1, P