Growth factor mediated signaling in pancreatic pathogenesis.
Growth factor mediated signaling in pancreatic pathogenesis.
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DOI：
10.3390/cancers3010841
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发表时间：
2011-02-24
期刊：
影响因子：
5.2
通讯作者：
Mukhopadhyay D
中科院分区：
文献类型：
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作者：
Nandy D;Mukhopadhyay D
从功能上讲，胰腺由两种类型的组织组成：外分泌和内分泌。胰腺外分泌系统疾病主要涉及急性和慢性胰腺炎。急性胰腺炎通常是良性的，而慢性胰腺炎被认为是发展胰腺癌的危险因素。胰腺癌是全球癌症相关死亡的第四大原因。大多数胰腺癌发生在外分泌组织中。胰腺内分泌肿瘤比较少见，通常比外分泌肿瘤侵袭性小。然而，胰腺内分泌紊乱，糖尿病，是发病率和死亡率的主要原因。重要的是，不同的生长因子及其受体在胰腺发病机制中起关键作用。因此，更好地了解各种生长因子如何影响胰腺炎和胰腺癌是必要的，以确定适当的治疗。本章介绍了不同的生长因子，如血管内皮生长因子（VEGF），胰岛素样生长因子（IGF），血小板衍生生长因子（PDGF），成纤维细胞生长因子（FGF），表皮生长因子（EGF），转化生长因子（TGF）在各种胰腺病理生理的作用。最后，不同的生长因子轴之间的串扰和各自的信号转导机制，这是参与胰腺炎和胰腺癌，也进行了讨论。
Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed.