Antibodies to peripheral nerve myelin proteins in chronic inflammatory demyelinating polyradiculoneuropathy
Antibodies to peripheral nerve myelin proteins in chronic inflammatory demyelinating polyradiculoneuropathy
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DOI：
10.1111/j.1085-9489.2005.0010207.x
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发表时间：
2005-06-01
影响因子：
3.8
通讯作者：
Hughes, RAC
中科院分区：
文献类型：
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作者：
Allen, D;Giannopoulos, K;Hughes, RAC
慢性炎性脱髓鞘性多发性神经根神经病（CIDP）是一种获得性周围神经系统疾病，可能与自身免疫发病机制有关。在大多数患者中，责任自身抗原的性质尚不清楚。我们使用Western免疫印迹技术寻找外周神经蛋白抗原的抗体。32例COP患者中的8例（25%）、37例格林-巴利综合征（GBS）患者中的12例（32%）、30例慢性特发性轴突性多发性神经病患者中的0例（0%）和39例健康对照受试者中的2例（5%）的血清含有抗外周神经蛋白抗体。CIDP（p = 0.04）和GBS（p = 0.003）患者中此类抗体的频率显著高于正常对照受试者。对于CIDP患者，抗体在女性和对静脉注射免疫球蛋白或血浆置换治疗有反应的患者中更常见，但趋势不显著。最常见的抗体针对28 kDa的条带，类似于针对髓鞘蛋白零（PO）的单克隆抗体标记的条带。6例COP和7例GBS患者血清与此条带反应。这些结果支持这样的观点，即髓鞘蛋白，特别是PO的抗体，存在于一些CUP和GBS患者的血清中。
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired disorder of the peripheral nervous system with a probable auto-immune pathogenesis. The nature of the responsible autoantigens is unclear in most patients. We used the Western immunoblot technique to seek antibodies to peripheral nerve protein antigens. Sera from eight of 32 (25%) COP patients, 12 of 37 (32%) Guillain-Barre syndrome (GBS) patients, zero of 30 (0%) chronic idiopathic axonal polyneuropathy patients and two of 39 (5%) healthy control subjects contained anti-peripheral nerve protein antibodies. The frequency of such antibodies was significantly greater in both CIDP (p = 0.04) and GBS (p = 0.003) patients than in normal control subjects. For CIDP patients, there were nonsignificant trends for antibodies to be more common in females and in those who responded to treatment with either intravenous immunoglobulin or plasma exchange. The commonest antibodies were directed against a band at 28 kDa, resembling that labelled by a monoclonal antibody against myelin protein zero (PO). Six COP and seven GBS patients' sera reacted with this band. These results support the view that antibodies to myelin proteins, and especially PO, are present in the serum of some patients with CUP and GBS.