The putative visual word form area is functionally connected to the dorsal attention network.
The putative visual word form area is functionally connected to the dorsal attention network.
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DOI：
10.1093/cercor/bhr100
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发表时间：
2012-03
期刊：
影响因子：
3.7
通讯作者：
Alecia C. Vogel;F. Miezin;S. Petersen;B. Schlaggar
中科院分区：
文献类型：
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作者：
Alecia C. Vogel;F. Miezin;S. Petersen;B. Schlaggar
假定的视觉词形区（pVWFA）是单个词阅读研究中最一致激活的区域（即，Vigneau et al. 2006），但其功能仍然是一个有争议的问题。pVWFA可以主要用于阅读，或者它可以是用于阅读但也用于其他视觉任务的更通用的视觉处理器。在这里，静息态功能连接磁共振成像（rs-fcMRI）用于表征pVWFA的功能关系，以帮助判断这些可能性之间。rs-fcMRI基于在休息时发生的血氧水平依赖性活动的缓慢波动中的相关性来定义关系。在这项研究中，rs-fcMRI相关性显示pVWFA和阅读相关区域之间的关系不大，但pVWFA和背侧注意区域之间的关系很强，被认为是与空间和功能的注意。pVWFA与背侧注意网络区域之间的rs-fcMRI相关性随着年龄和阅读技能的增加而增加，而pVWFA与阅读相关区域之间的相关性则不增加。这些结果表明，pVWFA并不主要用于阅读，而是一种更通用的视觉处理器，用于其他视觉任务，以及阅读。
The putative visual word form area (pVWFA) is the most consistently activated region in single word reading studies (i.e., Vigneau et al. 2006), yet its function remains a matter of debate. The pVWFA may be predominantly used in reading or it could be a more general visual processor used in reading but also in other visual tasks. Here, resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) is used to characterize the functional relationships of the pVWFA to help adjudicate between these possibilities. rs-fcMRI defines relationships based on correlations in slow fluctuations of blood oxygen level-dependent activity occurring at rest. In this study, rs-fcMRI correlations show little relationship between the pVWFA and reading-related regions but a strong relationship between the pVWFA and dorsal attention regions thought to be related to spatial and feature attention. The rs-fcMRI correlations between the pVWFA and regions of the dorsal attention network increase with age and reading skill, while the correlations between the pVWFA and reading-related regions do not. These results argue the pVWFA is not used predominantly in reading but is a more general visual processor used in other visual tasks, as well as reading.