Age‐associated decrease in histamine‐induced vasodilatation may be due to reduction of cyclic GMP formation
Age‐associated decrease in histamine‐induced vasodilatation may be due to reduction of cyclic GMP formation
复制标题
年龄相关的组胺诱导的血管舒张减少可能是由于环 GMP 形成的减少
DOI：
10.1111/j.1476-5381.1988.tb11734.x
复制
发表时间：
1988
影响因子：
7.3
通讯作者：
H. Araki
中科院分区：
文献类型：
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作者：
H. Moritoki;Asao Tanioka;Y. Maeshiba;T. Iwamoto;Y. Ishida;H. Araki
1研究了增龄对组胺诱导的大鼠胸主动脉血管舒张和环鸟苷酸生成的影响。2组胺诱导的主动脉扩张由H1受体介导，并依赖于内皮。3组胺引起3-4周龄大鼠动脉最大扩张，8 - 56周龄大鼠逐渐减少，100周龄大鼠几乎测不到扩张。4组胺诱导4周龄大鼠主动脉环GMP产生，而cAMP水平无明显变化。组胺引起的环GMP水平的增加也随着年龄的增长而下降，在8周龄时约为70%，在50-60周龄时约为50%，在130周龄时约为10%。5去除内皮细胞完全消除了组胺诱导的cGMP增加。[6]硝普钠的扩张作用，通过直接刺激鸟苷酸环化酶（而不是间接通过内皮衍生舒张因子EDRF）来增强环GMP的产生，也会导致年龄相关的衰减。8-溴环GMP刺激环GMP依赖性蛋白激酶的扩张作用也在衰老过程中下降。这些结果表明，衰老降低了内皮细胞产生EDRF的能力，EDRF刺激鸟苷酸环化酶，从而减少了环GMP的产生。因此，衰老过程中动脉对组胺的扩张反应降低可能是由于内皮功能丧失和鸟苷酸环化酶活性降低。环GMP依赖性蛋白激酶活性的改变也可能参与了年龄相关的变化。
1 The effects of aging on histamine‐induced vasodilatation and cyclic GMP production in rat thoracic aorta were investigated. 2 This histamine‐induced dilatation of the aorta was mediated by H1‐receptors and was dependent on the endothelium. 3 Histamine induced the greatest dilatation of arteries of 3–4 week old rats, progressively less of those of rats of 8 to 56 weeks old, and scarcely detectable dilatation of those of 100 week old rats. 4 Histamine induced cyclic GMP production in aorta from rats of 4 weeks old, with no change in the cyclic AMP level. This increase in the cyclic GMP level induced by histamine also decreased with age, being about 70% as great at 8 weeks, 50% as great at 50–60 weeks, and 10% as great at 130 weeks of age. 5 Removal of the endothelium completely abolished the histamine‐induced increase in cyclic GMP. 6 The dilator effect of nitroprusside, which enhances cyclic GMP production by stimulating guanylate cyclase directly (not indirectly via the endothelium derived relaxing factor, EDRF), also snowed age‐related attenuation. 7 The dilator effect of 8‐bromo cyclic GMP, which stimulates cyclic GMP‐dependent protein kinase, also decreased during aging. 8 These results suggest that aging reduces the ability of the endothelium to produce EDRF, which stimulates guanylate cyclase, and so decreases cyclic GMP production. Thus the decreased dilator response of the arteries to histamine during aging is probably due to both loss of endothelial function and reduction of guanylate cyclase activity. Alteration of cyclic GMP‐dependent protein kinase activity may also participate in the age‐related changes.
DOI：
--
发表时间：
1985-03
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
W. Martin;G. Villani;D. Jothianandan;R. Furchgott
通讯作者：
W. Martin;G. Villani;D. Jothianandan;R. Furchgott
内皮依赖性和硝基血管舒张剂诱导的血管平滑肌松弛：环 GMP 的作用。
DOI：
--
发表时间：
1983
期刊：
Journal of cyclic nucleotide and protein phosphorylation research
影响因子：
--
作者：
Rapoport,RM;Murad,F
通讯作者：
Murad,F