Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria.
Heme-dependent metalloregulation by the iron response regulator (Irr) protein in Rhizobium and other Alpha-proteobacteria.
复制标题
根瘤菌和其他α-变形菌中铁反应调节剂（Irr）蛋白的血红素依赖性金属调节。
DOI：
10.1007/s10534-008-9192-1
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
O'Brian,MarkR
中科院分区：
文献类型：
--
作者：
Small,SandraK;Puri,Sumant;O'Brian,MarkR
Perception and response to nutritional iron by bacteria is essential for viability, and for the ability to adapt to the environment. The iron response regulator (Irr) is part of a novel regulatory scheme employed byRhizobiumand other Alpha-Proteobacteria to control iron-dependent gene expression.Bradyrhizobium japonicumsenses iron through the status of heme biosynthesis to regulate gene expression, thus it responds to an iron-dependent process rather than to iron directly. Irr mediates this response by interacting directly with ferrochelatase, the enzyme that catalyzes the final step in heme biosynthesis. Irr is expressed under iron limitation to both positively and negatively modulate gene expression, but degrades in response to direct binding to heme in iron-sufficient cells. Studies withRhizobiumreveal that the regulation of iron homeostasis in bacteria is more diverse than has been generally assumed.
