FALSE-POSITIVE HUMAN-IMMUNODEFICIENCY-VIRUS TESTING IN PATIENTS WITH LUPUS-ERYTHEMATOSUS
FALSE-POSITIVE HUMAN-IMMUNODEFICIENCY-VIRUS TESTING IN PATIENTS WITH LUPUS-ERYTHEMATOSUS
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DOI：
10.1016/s0049-0172(05)80021-6
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发表时间：
1993-08-01
影响因子：
5
通讯作者：
WALLACE, DJ
中科院分区：
文献类型：
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作者：
BARTHEL, HR;WALLACE, DJ
对系统性红斑狼疮 (SLE) 患者进行人类免疫缺陷病毒 (HIV) 感染检测会导致 ELISA 结果阳性率高于预期，并且蛋白质印迹结果不确定。由于大多数此类患者缺乏 HIV 感染的危险因素，并且 SLE 和 HIV 感染共存的情况极为罕见，因此这些结果大多数为假阳性。报道了两例 HIV 检测假阳性的病例，并回顾了相关文献。此外，还讨论了用于评估不确定的 HIV 蛋白质印迹测试的 Celum 算法，该算法对于狼疮患者尤其有价值。
Testing for human immunodeficiency virus (HIV) infection in patients with systemic lupus erythematosus (SLE) leads to a higher than expected rate of positive ELISA results and indeterminate Western blot results. Because most of these patients lack any risk factors for HIV infection and the coexistence of SLE and HIV infection is extremely rare, most of these results represent false-positives. Two cases of false-positive HIV tests are reported and the related literature is reviewed. Further, Celum's algorithm for evalauting indeterminate HIV Western blot tests, which is especially valuable in lupus patients, is discussed.