Learning Stimulus Intervals-Adaptive Timing of Conditioned Purkinje Cell Responses
Learning Stimulus Intervals-Adaptive Timing of Conditioned Purkinje Cell Responses
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DOI：
10.1007/s12311-011-0264-3
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发表时间：
2011-09-01
期刊：
影响因子：
3.5
通讯作者：
Hesslow, Germund
中科院分区：
文献类型：
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作者：
Jirenhed, Dan-Anders;Hesslow, Germund
经典条件反射运动反应，如眨眼反应，是一个实验模型的联想学习和自适应时间的运动。条件性眨眼将在非条件性眨眼诱发刺激的预期开始附近具有其最大幅度，并且其适应条件性刺激和非条件性刺激之间的间隔的变化。先前的研究表明，眨眼条件反射可以使小脑浦肯野细胞学习暂停对条件刺激的反应。根据小脑皮质条件反射模型，这种条件性浦肯野细胞反应驱动了明显的眨眼。如果是这样，该模型预测，浦肯野细胞反应的时间属性反映了明显的行为。为了测试这一预测，浦肯野细胞的活动在体内记录进行去大脑雪貂在条件反射，使用直接刺激小脑苔藓和攀爬纤维传入条件和非条件刺激。结果表明，浦肯野细胞不仅发展的变化，反应条件刺激。他们还学习一个特定的时间响应曲线，其中的时间，不仅开始和最大值，而且偏移，是由条件和非条件刺激之间的时间间隔确定的。
Classical conditioning of motor responses, such as the eyeblink response, is an experimental model of associative learning and of adaptive timing of movements. A conditioned blink will have its maximum amplitude near the expected onset of the unconditioned blink-eliciting stimulus and it adapts to changes in the interval between the conditioned and unconditioned stimuli. Previous studies have shown that an eyeblink conditioning protocol can make cerebellar Purkinje cells learn to pause in response to the conditioned stimulus. According to the cerebellar cortical conditioning model, this conditioned Purkinje cell response drives the overt blink. If so, the model predicts that the temporal properties of the Purkinje cell response reflect the overt behaviour. To test this prediction, in vivo recordings of Purkinje cell activity were performed in decerebrate ferrets during conditioning, using direct stimulation of cerebellar mossy and climbing fibre afferents as conditioned and unconditioned stimuli. The results show that Purkinje cells not only develop a change in responsiveness to the conditioned stimulus. They also learn a particular temporal response profile where the timing, not only of onset and maximum but also of offset, is determined by the temporal interval between the conditioned and unconditioned stimuli.