Childhood Obesity and Vascular Phenotypes A Population Study
Childhood Obesity and Vascular Phenotypes A Population Study
复制标题
DOI：
10.1016/j.jacc.2012.08.1017
复制
发表时间：
2012-12-25
影响因子：
24
通讯作者：
Deanfield, John E.
中科院分区：
文献类型：
--
作者：
Charakida, Marietta;Jones, Alexander;Deanfield, John E.
目的本研究旨在评估儿童期肥胖与青春期前儿童血管表型的关系。背景肥胖儿童的早期代谢结果一直被证实，但任何血管变化的时间过程和发展仍然在很大程度上未被探索。对来自ALSPAC（雅芳父母和儿童纵向研究）的576名10至11岁的儿童进行了研究。儿童期超重和肥胖是基于与血管测量同期的体重指数，并得到其他肥胖测量的支持，包括脂肪量和双能x线吸收测量的腰围。心率血压肱动脉血流介导的扩张结果超重和肥胖儿童的心率高于正常儿童，（平均72.4 +/- 11次/分和74.6 +/- 12.2次/分vs. 71.7 +/- 11次/分）和收缩压（平均106.3 +/- 9.1 mm Hg和108 +/- 10.2 mm Hg vs. 103.6 +/- 9 mm Hg）与正常体重的同龄人相比。然而，肥胖儿童有较大的肱动脉直径和静息和充血血流量，轻微增加内皮功能（更高的流量介导的扩张：平均8.2 +/- 3.2% vs. 8.1 +/- 3.3%）和更低的动脉僵硬度（脉搏波速度：平均6.99 +/- 1.0 m/s vs. 7.05 +/- 1.23 m/s）与正常体重儿童相比。这些研究结果没有解释代谢differentiation.Conclusions更大的儿童肥胖症与不利的心脏代谢危险因素，但没有证据表明，在9至11岁的血管损伤。这可能代表了儿童时期对肥胖充血状态的生理适应。（J Am科尔心脏病学杂志2012;60：2643-50）（C）美国心脏病学会基金会2012年
Objectives This study sought to assess the associations of childhood adiposity with vascular phenotype in pre-pubertal children.Background The early-life metabolic consequences have consistently been demonstrated in obese children, but the time course and development of any vascular changes remain largely unexplored.Methods A total of 6,576 children age 10 to 11 years from the ALSPAC (Avon Longitudinal Study of Parents and Children) were studied. Childhood overweight and obesity were based on body mass index contemporary to vascular measures and supported by other adiposity measures, including fat mass and waist circumference on dual-energy x-ray absorptiometry. Heart rate, blood pressure, flow-mediated dilation in the brachial artery, and carotid to radial pulse wave velocity were measured in all children.Results Overweight and obese children had higher heart rates (mean 72.4 +/- 11 beats/min and 74.6 +/- 12.2 beats/min vs. 71.7 +/- 11 beats/min) and systolic blood pressures (mean 106.3 +/- 9.1 mm Hg and 108 +/- 10.2 mm Hg vs. 103.6 +/- 9 mm Hg) compared with normal-weight peers. However, obese children had greater brachial diameters and resting and hyperemic blood flow, marginally increased endothelial function (higher flow-mediated dilation: mean 8.2 +/- 3.2% vs. 8.1 +/- 3.3%), and lower arterial stiffness (pulse wave velocity: mean 6.99 +/- 1.0 m/s vs. 7.05 +/- 1.23 m/s) compared with normal-weight children. These findings were not explained by metabolic differences.Conclusions Greater childhood adiposity is associated with adverse cardiometabolic risk factors, but with no evidence of vascular damage at age 9 to 11 years. This could represent physiological adaptation to the hyperemic state of adiposity in childhood. (J Am Coll Cardiol 2012;60:2643-50) (C) 2012 by the American College of Cardiology Foundation