Primordial spliceosomal introns were probably U2-type
Primordial spliceosomal introns were probably U2-type
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DOI：
10.1016/j.tig.2008.09.002
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发表时间：
2008-11-01
影响因子：
11.4
通讯作者：
Koonin, Eugene V.
中科院分区：
文献类型：
--
作者：
Basu, Malay Kumar;Rogozin, Igor B.;Koonin, Eugene V.
真核生物的两种剪接体内含子U2和U12具有不同的剪接信号，并被不同的剪接体切割。原始内含子的性质仍然不确定。将在真核进化过程中保持位置的内含子插入位点的氨基酸分布与人和拟南芥U2和U12内含子的分布进行比较，发现与U2非常相似，但与U12不同。因此，原始剪接体内含子很可能是U2型。
The two types of eukaryotic spliceosomall introns, U2 and U12, possess different splice signals and are excised by distinct spliceosomes. The nature of the primordial introns remains uncertain. A comparison of the amino acid distributions at insertion sites of introns that retained their positions throughout eukaryotic evolution with the distributions for human and Arabidopsis thaliana U2 and U12 introns reveals close similarity with U2 but not U12. Thus, the primordial spliceosomall introns were, most likely, U2-type.