Does cerebral vasospasm result from denervation supersensitivity?
Does cerebral vasospasm result from denervation supersensitivity?
复制标题
脑血管痉挛是由去神经超敏反应引起的吗？
作者：
Duff,TA;Feilbach,JA;Scott,G
本研究探讨了去神经超敏感在脑血管痉挛发生中的作用。通过切除颈上神经节或大池注射6-羟多巴胺来完成猫基底动脉的肾上腺素能去神经。测定了正常动脉和去神经动脉的体内剂量-反应特性，在局部应用血清素、去甲肾上腺素、肾上腺素、新鲜血液或孵育血液之间没有发现显著差异。此外，对体外培养的猫血的分析显示，血清素、去甲肾上腺素和肾上腺素的水平随着时间的推移而降低，而血红蛋白和高铁血红蛋白的水平则在第14天上升。本研究结果表明，肾上腺素能失神经支配不是脑血管痉挛的原因，无论其机制如何，血红蛋白都比其他药物更有可能发挥作用。
This study examined the role of denervation supersensitivity in the development of cerebral vasospasm. Adrenergic denervation of cat basilar artery was accomplished by resection of the superior cervical ganglia or by injection of 6-hydroxydopamine into the cisterna magna. In vivo dose-response characteristics were determined for normal and for denervated arteries, and no significant differences were found between topical applications of serotonin, norepinephrine, epinephrine, fresh blood, or incubated blood. In addition, analysis of cat blood incubated in vitro revealed that the levels of serotonin, norepinephrine, and epinephrine diminished over time, whereas levels of hemoglobin and methemoglobin increased up to Day 14. The results of this study indicate that adrenergic denervation is not the cause of cerebral vasospasm and that, whatever the mechanism, hemoglobin is far more likely to play a role than are the other agents.