Acute pharmacological activity of intravenous cocaine in the rhesus monkey.
Acute pharmacological activity of intravenous cocaine in the rhesus monkey.
复制标题
静脉注射可卡因在恒河猴中的急性药理活性。
DOI：
--
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
A. Kibbe
中科院分区：
文献类型：
--
作者：
M. Wilson;J. A. Bedford;J. Buelke;A. Kibbe
The effects of the intravenous administration of cocaine (0.05-5.0 mg/kg) on body temperature, heart rate, respiration rate and several unconditioned behavioral categories were ascertained in unanesthetized male rhesus monkeys. Statistically significant increases in body temperature, respiration rate and heart rate occurred only after the largest dosage tested. Subjective increases in pupil size, activity, reactivity and vocalization as well as the occurrence of stereotyped behaviors, mydriasis and refusal to ingest fruit, were observed following injection with 0.2, 0.5 mg/kg and 5.0 mg/kg. A large degree of consistent intersubject variability in the magnitude of these responses was present. There was no consistent correlation across subjects between the magnitude of these responses and the plasma level of cocaine. However, within a given subject a direct correlation existed between these parameters.
