Argusides D and E, two new cytotoxic triterpene glycosides from the sea cucumber Bohadschia argus JAEGER
Argusides D and E, two new cytotoxic triterpene glycosides from the sea cucumber Bohadschia argus JAEGER
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DOI：
10.1002/cbdv.200890131
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Wang, Zeng-Lei
中科院分区：
文献类型：
--
作者：
Liu, Bao-Shu;Yi, Yang-Hua;Wang, Zeng-Lei
两个新的三萜苷，即人参皂苷D和E（分别为1和2），从采自中国南海的乌鳢海参（Bohadschia argus JAEGER）中分离得到一种新的海参毒素。它们的结构已通过光谱分析（ESI-MS和1D-和2D-NMR）和化学证据确定。化合物1和2都具有含C（9）=C（11）键的全甾烷型三萜苷元，在C（12）上具有OH基团，和四糖部分，但在侧链上不同。这两种糖苷对四种人肿瘤细胞系A549、HCT-116、HepG 2和MCF-7表现出显著的细胞毒性。
Two new triterpene glycosides, argusides D and E (1 and 2, resp.), have been isolated from the sea cucumber Bohadschia argus JAEGER collected in the South China Sea. Their structures have been established by spectral analysis (ESI-MS, and 1D- and 2D-NMR) and chemical evidence. Compounds 1 and 2 both possess an holostane-type triterpene aglycone with a C(9)=C(11) bond, an OH group at C(12), and tetrasaccharide moieties, but differ in the side chains. The two glycosides exhibited significant cytotoxicities against four human tumor cell lines, A549, HCT-116, HepG2, and MCF-7.