Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D. A preliminary study.
Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D. A preliminary study.
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DOI：
10.1001/archderm.1988.01670120018003
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发表时间：
1988-12
影响因子：
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通讯作者：
L. Matsuoka;J. Wortsman;Nancy Hanifan;M. Holick
中科院分区：
文献类型：
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作者：
L. Matsuoka;J. Wortsman;Nancy Hanifan;M. Holick
防晒霜阻止吸收阳光光谱负责皮肤合成维生素D（紫外线B）。本研究提示我们的观察抑制皮肤维生素D的形成由一个单一的应用程序的防晒剂。本文测定了20例长期服用对氨基苯甲酸（PABA）者和20例年龄、日照匹配的对照者的维生素D体内储备指数、血清25-羟维生素D（25-OH-D）水平。长期使用PABA者的血清25-OH-D水平显著低于正常对照组：40.2 +/- 3.2 vs 91.3 +/- 6.2 nmol/L。此外，维生素D缺乏症，即25-OH-D水平低于20.0 nmol/L，被认为是在两个PABA用户和没有控制。这项初步研究表明，长期使用PABA可能与某些人体内维生素D储存量低有关。
Sunscreens block the absorption of the sunlight spectrum responsible for the cutaneous synthesis of vitamin D (ultraviolet B). The present study was prompted by our observation of suppression of cutaneous vitamin D formation by a single application of sunscreening agents. We measured the index of vitamin D body store, serum 25-hydroxyvitamin D (25-OH-D) level, in 20 long-term users of p-aminobenzoic acid (PABA) and in 20 controls matched by age and exposure to sunlight. Serum 25-OH-D levels were significantly lower among long-term PABA users than among normal controls: 40.2 +/- 3.2 vs 91.3 +/- 6.2 nmol/L. Furthermore, vitamin D deficiency, ie, 25-OH-D levels below 20.0 nmol/L, was seen in two PABA users and in none of the controls. This preliminary study suggests that long-term use of PABA may be associated with low body stores of vitamin D in some persons.