Palladium catalyzed selective arylation of o-carboranes via B(4)-H activation: amide induced regioselectivity reversal
Palladium catalyzed selective arylation of o-carboranes via B(4)-H activation: amide induced regioselectivity reversal
复制标题
钯通过 B(4)-H 活化催化邻碳硼烷的选择性芳基化：酰胺诱导的区域选择性逆转
DOI：
10.1039/c8cc08193j
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发表时间：
2018
影响因子：
4.9
通讯作者：
Yang Junxiao
中科院分区：
文献类型：
--
作者：
Xu Tao-Tao;Cao Ke;Zhang Cai-Yan;Wu Ji;Jiang Linhai;Yang Junxiao
通过在笼型B（9）上引入酰胺改变硼顶点的电荷分布，发展了邻碳硼烷的Suzuki-Miyaura偶联选择性B（4）芳基化反应.合成了一系列不同活性基团修饰的邻位碳硼烷衍生物，并将其转化为新型的三取代巢式碳硼烷并恶唑化合物，在硼中子俘获治疗、有机金属及配位化学等方面具有潜在的应用价值。
By changing the charge distribution of boron vertices via introducing an amide on cage B(9), the selective B(4) arylation of o-carboranes via Suzuki–Miyaura coupling has been developed. A series of o-carborane derivatives decorated with diverse active groups have been synthesized with moderate to good yields, which have been proved to be further transformed to a novel kind of tri-substituted nido-carborane fused oxazole with potential application in boron neutron capture therapy, organometallic as well as coordination chemistry.