Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review.
Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review.
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DOI：
10.1080/1354750x.2017.1339294
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Mu L
中科院分区：
文献类型：
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作者：
Desai G;Chu L;Guo Y;Myneni AA;Mu L
本文综述了使用生物标志物评估空气污染暴露或了解其影响围产期结局的机制的孕妇研究。我们搜索了PubMed和Google Scholar数据库，找到了29篇文章，大多数是队列研究。插值模型最常用于评估接触。最一致的正相关是在整个怀孕期间多环芳烃（PAH）暴露和脐带血PAH DNA加合物之间。暴露于颗粒物（PM）和二氧化氮（NO2）与线粒体DNA（mtDNA）含量呈一致的负相关，特别是在怀孕的第三个月。没有一种污染物与本综述中的所有生物标志物表现出强烈的相关性。C-反应蛋白（CRP）和氧化应激标志物增加，而端粒长度随着空气污染暴露的增加而减少。胎盘整体DNA甲基化和mtDNA甲基化显示出与空气污染暴露相反的结果，其背后的机制尚不清楚。除了PAH DNA加合物和mtDNA含量的研究外，大多数研究都没有提供足够的证据来表征关键的暴露窗口。使用生物标志物的进一步研究是必要的，以了解空气污染和围产期结局之间的关系。
This review focuses on studies among pregnant women that used biomarkers to assess air pollution exposure, or to understand the mechanisms by which it affects perinatal outcomes. We searched PubMed and Google scholar databases to find articles We found 29 articles, mostly consisting of cohort studies. Interpolation models were most frequently used to assess exposure. The most consistent positive association was between polycyclic aromatic hydrocarbon (PAH) exposure during entire pregnancy and cord blood PAH DNA adducts. Exposure to particulate matter (PM) and nitrogen dioxide (NO2) showed consistent inverse associations with mitochondrial DNA (mtDNA) content, particularly in the third trimester of pregnancy. No single pollutant showed strong associations with all the biomarkers included in this review. C-reactive proteins (CRPs) and oxidative stress markers increased, whereas telomere length decreased with increasing air pollution exposure. Placental global DNA methylation and mtDNA methylation showed contrasting results with air pollution exposure, the mechanism behind which is unclear. Most studies except those on PAH DNA adducts and mtDNA content provided insufficient evidence for characterizing a critical exposure window. Further research using biomarkers is warranted to understand the relationship between air pollution and perinatal outcomes.