Proximodistal Organization of the CA2 Hippocampal Area
Proximodistal Organization of the CA2 Hippocampal Area
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DOI：
10.1016/j.celrep.2019.01.060
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发表时间：
2019-02-12
期刊：
影响因子：
8.8
通讯作者：
Menendez de la Prida, Liset
中科院分区：
文献类型：
--
作者：
Fernandez-Lamo, Ivan;Gomez-Dominguez, Daniel;Menendez de la Prida, Liset
近远轴被认为是海马的主要组织原则。在海马体和其他大脑结构之间的界面，CA2显然打破了这一规则。该区域参与社会，时间和上下文记忆功能，但机制仍然难以捉摸。在这里，我们揭示了细胞类型的异质性和特征性的表达梯度的转录因子Sox 5内CA2大鼠。使用细胞内和细胞外的记录，然后通过神经化学鉴定的单细胞，我们发现显着的proximodistal趋势的突触活动，阈下膜电位，和相位锁定发射耦合到θ和γ振荡。相移膜电位和相反的proximodistal与theta汇和源在不同层的相关性支持不同的电流发生器的影响。大鼠在线性迷宫中的CA2振荡活动和位置编码反映了近远侧状态依赖的趋势。提示CA 2的结构和功能沿着海马近远轴分布。
The proximodistal axis is considered a major organizational principle of the hippocampus. At the interface between the hippocampus and other brain structures, CA2 apparently breaks this rule. The region is involved in social, temporal, and contextual memory function, but mechanisms remain elusive. Here, we reveal cell-type heterogeneity and a characteristic expression gradient of the transcription factor Sox5 within CA2 in the rat. Using intracellular and extracellular recordings followed by neurochemical identification of single cells, we find marked proximodistal trends of synaptic activity, subthreshold membrane potentials, and phase-locked firing coupled to theta and gamma oscillations. Phase-shifting membrane potentials and opposite proximodistal correlations with theta sinks and sources at different layers support influences from different current generators. CA2 oscillatory activity and place coding of rats running in a linear maze reflect proximodistal state-dependent trends. We suggest that the structure and function of CA2 are distributed along the proximodistal hippocampal axis.